Department of Orthopedics, 88th Hospital, Tai'an, Shandong, China.
Injury. 2012 Jun;43(6):794-801. doi: 10.1016/j.injury.2011.09.013. Epub 2011 Oct 20.
Loss of oligodendrocytes and demyelination further impair neural function after spinal cord injury (SCI). Replacement of lost oligodendrocytes and improvement of myelination have a therapeutic significance in treatment of SCI. Here, we transplanted oligodendrocyte precursor cells (OPCs) to improve myelination in a rat model of contusive SCI. The labelled OPCs were transplanted to injured cord 7 days after injury. As a result, the implanted cells still survived in vivo 8 weeks after transplantation. They proliferated, integrated and differentiated in the injured cord. In the OPCs-treated rats, enhanced myelination in the lesioned area was observed and substantial improvement of motor function and nerve conduction was also recorded. Thus, this study provides strong evidence to support that transplantation of OPCs could improve myelination of injured cord and enhance functional recovery after contusive SCI.
少突胶质细胞的丧失和脱髓鞘进一步损害脊髓损伤（SCI）后的神经功能。在 SCI 的治疗中，替代丢失的少突胶质细胞和改善髓鞘形成具有治疗意义。在这里，我们移植了少突胶质前体细胞（OPCs），以改善外伤性 SCI 大鼠的髓鞘形成。在损伤后 7 天，将标记的 OPC 移植到损伤的脊髓中。结果，移植后 8 周，植入的细胞在体内仍然存活。它们在损伤的脊髓中增殖、整合和分化。在 OPCs 治疗的大鼠中，观察到损伤区域的髓鞘形成增强，运动功能和神经传导也有显著改善。因此，这项研究为 OPCs 移植可以改善外伤性 SCI 损伤脊髓的髓鞘形成并增强功能恢复提供了有力证据。
