Khoo S K, Munro C, Battistutta D
University of Queensland, Department of Obstetrics and Gynaecology, Royal Brisbane Hospital, Herston.
Med J Aust. 1990 Aug 20;153(4):189-92. doi: 10.5694/j.1326-5377.1990.tb136857.x.
The therapeutic effectiveness of evening primrose oil (Efamol, Vita-Glow) in the relief of 10 symptoms associated with premenstrual syndrome (PMS) as well as menstrual symptoms was studied in 38 women. The prospective trial was randomised, double-blind and placebo-controlled and was crossed-over after three cycles. Although the results showed an improvement in symptoms of PMS during the trial, no significant differences in the scoring between the active and placebo groups were found over six cycles. No "carry-over" effect of active medication was observed; the beneficial effect on all symptoms (psychological, fluid retention, breast) was rapid, the scores decreasing in the first cycle but increasing slightly at the change-over period after the third cycle, irrespective of whether the active or placebo medication was next given. These findings indicate that the improvement experienced by these women with moderate PMS was solely a placebo effect.
对38名女性进行了研究，以考察月见草油（Efamol，Vita-Glow）缓解与经前综合征（PMS）相关的10种症状以及月经症状的治疗效果。该前瞻性试验为随机、双盲和安慰剂对照试验，在三个周期后进行交叉。尽管结果显示试验期间PMS症状有所改善，但在六个周期中，活性药物组和安慰剂组之间的评分没有显著差异。未观察到活性药物的“延续”效应；对所有症状（心理、液体潴留、乳房）的有益作用迅速，评分在第一个周期下降，但在第三个周期后的转换期略有上升，无论接下来给予的是活性药物还是安慰剂。这些发现表明，这些患有中度PMS的女性所经历的改善仅仅是安慰剂效应。
