Collins A, Cerin A, Coleman G, Landgren B M
Department of Psychiatry, Karolinska Institute, Stockholm, Sweden.
Obstet Gynecol. 1993 Jan;81(1):93-8.
To determine whether essential fatty acids are effective in the treatment of premenstrual syndrome (PMS).
In a randomized, double-blind, crossover trial, we studied 27 women diagnosed with PMS over ten menstrual cycles and 22 symptom-free controls over one cycle. The first cycle was used for diagnostic assessment. For the women with PMS, placebos were administered during the second cycle. This was followed by randomization to four cycles of active treatment with essential fatty acids and four cycles of placebo, with a crossover after completion of the fourth cycle. Assessment of symptoms and diagnosis of PMS were based on daily self-ratings made by the women throughout the study.
Treatment with essential fatty acids did not reduce premenstrual symptoms or symptom cyclicity. However, time had a significant effect on a number of symptoms, indicating either a placebo effect or an effect from participation in the study. Women with PMS had a significantly higher frequency of dysmenorrhea and familial PMS than did the symptom-free controls.
Treatment with essential fatty acids is ineffective therapy for PMS. The improvement we observed over time can be ascribed to either a placebo effect or participation in the study.
确定必需脂肪酸在治疗经前综合征（PMS）方面是否有效。
在一项随机、双盲、交叉试验中，我们对27名被诊断患有经前综合征的女性进行了超过十个月经周期的研究，并对22名无症状对照者进行了一个周期的研究。第一个周期用于诊断评估。对于患有经前综合征的女性，在第二个周期给予安慰剂。随后将其随机分为四个周期接受必需脂肪酸的积极治疗和四个周期接受安慰剂治疗，在第四个周期结束后进行交叉。经前综合征的症状评估和诊断基于女性在整个研究过程中的每日自我评分。
必需脂肪酸治疗并未减轻经前症状或症状的周期性。然而，时间对一些症状有显著影响，这表明可能存在安慰剂效应或参与研究产生的效应。患有经前综合征的女性痛经和家族性经前综合征的发生率显著高于无症状对照者。
必需脂肪酸治疗经前综合征无效。我们观察到的随时间的改善可能归因于安慰剂效应或参与研究。
