Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, 06100 Sihhiye, Ankara, Turkey.
Arch Gerontol Geriatr. 2012 Sep-Oct;55(2):257-60. doi: 10.1016/j.archger.2011.09.016. Epub 2011 Oct 21.
Vascular risk factors play a significant role in the pathogenesis and progression of AD. MPV is an index of platelet activation and may be a potential marker of inflammation to demonstrate the vascular damage in AD. The aim of the present study is to assess whether platelet volume would be useful in predicting vascular damage in AD. A total of 126 patients with AD (male/female: 44/82, mean age 76.2 ± 6.8 years) and 286 patients as controls with normal cognitive function (male/female: 123/163, mean age 75.2 ± 6.3 years) were enrolled in this cross-sectional study. MPV values were determined for all study participants. Mini-Mental State Examination (MMSE) and clock drawing tests (CDT) were performed for cognitive assessment, DSM-IV and NINCDS-ADRDA criteria were used for diagnosis of AD. The mean MPV values were significantly higher in AD group (8.46 ± 1.15 vs. 8.17 ± 0.90; p=0.011). In this study, significantly higher MPV values in patients with AD have been detected. Since increased MPV levels are usually considered as a vascular risk factor, the results of this study suggested the role of platelet activation in the vascular pathogenetic basis of AD.
血管危险因素在 AD 的发病机制和进展中起重要作用。MPV 是血小板活化的指标，可能是炎症的潜在标志物，可用于证明 AD 中的血管损伤。本研究旨在评估血小板体积是否可用于预测 AD 中的血管损伤。本横断面研究共纳入 126 例 AD 患者（男/女：44/82，平均年龄 76.2 ± 6.8 岁）和 286 例认知功能正常的对照组患者（男/女：123/163，平均年龄 75.2 ± 6.3 岁）。所有研究参与者均测定了 MPV 值。进行了简易精神状态检查（MMSE）和画钟试验（CDT）以进行认知评估，使用 DSM-IV 和 NINCDS-ADRDA 标准诊断 AD。AD 组的平均 MPV 值明显更高（8.46 ± 1.15 比 8.17 ± 0.90；p=0.011）。在这项研究中，检测到 AD 患者的 MPV 值明显更高。由于较高的 MPV 水平通常被认为是血管危险因素，因此本研究的结果提示了血小板活化在 AD 的血管发病机制基础中的作用。
