Department of Neurology, Balıkesir University, Turkey.
Turk J Med Sci. 2014;44(6):1060-6. doi: 10.3906/sag-1212-5.
BACKGROUND/AIM: Vascular risk factors play an important role in the progression of Alzheimer disease (AD). Mean platelet volume (MPV) is a determinant of platelet functionality and increased MPV is associated with an increased risk of vascular inflammation. Here we aimed to examine whether MPV could be used as a marker of vascular damage in AD and to discuss the relation between MPV and other vascular risk factors.
A total of 109 outpatients with AD and 81 healthy controls were included in this study. Diagnosis of AD was made according to defined criteria. The Turkish version of the Mini Mental State Examination (MMSE) was used for cognitive assessment. According to the test results, patients were divided into 2 subgroups, mild (MMSE ≥ 18) and moderate (MMSE < 18), and their MPV levels were compared.
MPV levels were higher in the AD group. There was no statistically significant difference between the moderate group and the mild group according to MPV values.
Increased MPV in patients with AD may point to platelet dysfunction. MPV is an indicator of increased in vivo platelet activation. Hence, platelets could be the link between vascular risk factors and AD. The assessment of MPV in patients with AD may help identify the patients that could benefit from additional antiplatelet therapy.
背景/目的：血管危险因素在阿尔茨海默病（AD）的进展中起着重要作用。平均血小板体积（MPV）是血小板功能的决定因素，MPV 增加与血管炎症风险增加相关。在此，我们旨在研究 MPV 是否可作为 AD 血管损伤的标志物，并探讨 MPV 与其他血管危险因素之间的关系。
本研究共纳入 109 名 AD 门诊患者和 81 名健康对照者。根据明确的标准诊断 AD。使用土耳其版简易精神状态检查（MMSE）进行认知评估。根据测试结果，将患者分为轻度（MMSE≥18）和中度（MMSE<18）两组，并比较其 MPV 水平。
AD 组的 MPV 水平较高。根据 MPV 值，中度组与轻度组之间无统计学差异。
AD 患者的 MPV 增加可能表明血小板功能障碍。MPV 是体内血小板活化增加的指标。因此，血小板可能是血管危险因素与 AD 之间的联系。对 AD 患者的 MPV 评估可能有助于确定那些可能从额外抗血小板治疗中获益的患者。
