Labor Krone, Siemensstr. 40, 32105 Bad Salzuflen, Germany.
Forensic Sci Int. 2012 May 10;218(1-3):3-9. doi: 10.1016/j.forsciint.2011.10.001. Epub 2011 Oct 22.
This paper addresses the suitability of ethyl glucuronide in hair (EtGH) strands other than 3cm for alcohol consumption. This issue will be addressed (a) by statistically comparing the distribution of EtGH results for 3cm hair strands to other hair strands analysed from 4126 cases and (b) by examining the stability of EtGH in an 8cm hair strand and two 12cm hair samples of two volunteers and a post-mortem case using 1cm segmental analysis. For 3464 driving license re-granting Medical and Psychological Assessment (MPA) cases, the detection of alcohol consumption using hair lengths longer than 3cm was never significantly less than for 3cm hair lengths, even up to 12cm hair lengths analysed non-segmented. For 662 non-MPA cases, where, in contrast to MPA cases, generally no abstinence was required, an increase in the EtGH positivity rate was observed with increasing hair length analysed up to 9cm, indicating that EtG-washout effects seem to play a minor role if any. For both MPA and non-MPA hair samples less than 3cm, a drastic, significant increase in the number of positive EtGH samples were observed, compared to 3cm hair lengths, strongly supportive of EtGH incorporation from sweat after a recent alcohol consumption. Segmental studies indicated that EtG is stable in the hair matrix up to 12cm long, hence supporting the above results. Even though both the statistical and the stability studies are preliminary results which need to be confirmed by other studies, they both provide evidence for the determination of alcohol consumption using EtGH in hair lengths longer than 3cm. Amendments to the Consensus of the Society of Hair Testing, the German driving license re-granting guidelines and EWDTS hair guidelines with respect to testing for abstinence and/or alcoholism are proposed for the benefit of the donors.
本文探讨了 3cm 以外的头发（EtGH）段用于酒精摄入检测的适宜性。本研究通过（a）比较 4126 例病例中 3cm 头发段和其他头发段的 EtGH 结果分布，（b）通过对两名志愿者和一名死后案例的 8cm 头发段和两段 12cm 头发样本进行 1cm 分段分析，研究 EtGH 在头发中的稳定性。在 3464 例驾驶执照重新发放医学和心理评估（MPA）案例中，使用 3cm 以上长度的头发检测酒精摄入，其结果从未显著低于 3cm 头发长度，甚至分析非分段的 12cm 头发长度也是如此。对于 662 例非 MPA 案例，与 MPA 案例相反，一般不需要禁欲，随着分析头发长度的增加，EtGH 阳性率呈上升趋势，直至 9cm，这表明 EtG 洗脱效应如果有的话，似乎作用较小。对于 MPA 和非 MPA 头发样本，小于 3cm 的头发样本中，与 3cm 头发长度相比，EtGH 阳性样本数量急剧增加，这强烈支持最近饮酒后 EtGH 从汗液中摄取的说法。分段研究表明，EtG 在长达 12cm 的头发基质中稳定，因此支持了上述结果。尽管统计和稳定性研究都是初步结果，需要其他研究来证实，但它们都为使用 EtGH 检测 3cm 以上长度的头发中酒精摄入提供了证据。为了捐赠者的利益，提出了对头发检测协会共识、德国驾驶执照重新发放指南和 EWDTS 头发指南中关于禁欲和/或酗酒检测的修订建议。
