Department of Physical Medicine and Rehabilitation, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.
Am J Phys Med Rehabil. 2011 Dec;90(12):1012-9. doi: 10.1097/PHM.0b013e31822dea1a.
The aim of this study was to investigate the presence of autonomic dysfunction in patients with osteoporosis.
This is a prospective controlled trial. Sixteen postmenopausal female patients with osteoporosis and 10 age-matched postmenopausal nonosteoporotic controls were included in the study. Participants were divided into the postmenopausal osteoporosis group and the nonosteoporotic control group according to bone mineral densities. Heart rate variability parameters and sympathetic skin responses were studied to evaluate autonomic functions.
The latencies of sympathetic skin responses obtained from both hands were significantly increased in the patient group when compared with the control group. The sympathetic skin response amplitude of the right hands and both feet of the patient group were found to be decreased significantly when compared with that of the control group. A 24-hr high-frequency value was significantly decreased in the patient group than in control group. A 24-hr low-/high-frequency value was significantly higher in the patient group than in the control group.
Autonomic dysfunction characterized with increased sympathetic and decreased parasympathetic activity may be present in osteoporosis, and cardiac functions in patients with osteoporosis may also be affected by accompanying autonomic dysfunction.
本研究旨在探讨骨质疏松症患者自主神经功能障碍的情况。
这是一项前瞻性对照试验。纳入了 16 名绝经后骨质疏松症女性患者和 10 名年龄匹配的非骨质疏松绝经后对照者。根据骨密度将参与者分为绝经后骨质疏松症组和非骨质疏松对照组。研究评估了自主神经功能，检测了心率变异性参数和交感皮肤反应。
与对照组相比，患者组双手的交感皮肤反应潜伏期明显延长。与对照组相比，患者组右手和双脚的交感皮肤反应振幅明显降低。与对照组相比，患者组 24 小时高频值显著降低。患者组 24 小时低/高频值明显高于对照组。
骨质疏松症患者可能存在以交感神经兴奋和副交感神经活性降低为特征的自主神经功能障碍，且骨质疏松症患者的心脏功能也可能受到伴随的自主神经功能障碍的影响。
