Gould Robert W, Porrino Linda J, Nader Michael A
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157-1083, USA,
Curr Top Behav Neurosci. 2012;11:25-44. doi: 10.1007/7854_2011_168.
This chapter highlights the use of nonhuman primate models of cocaine addiction and the use of positron emission tomography (PET) imaging to study the role of individual differences in vulnerability and how environmental and pharmacological variables can impact cocaine abuse. The chapter will describe studies related to the dopamine (DA) neurotransmitter system, and focus primarily on the D2-like DA receptor, the DA transporter and the use of fluorodeoxyglucose to better understand the neuropharmacology of cocaine abuse. The use of nonhuman primates allows for within-subject, longitudinal studies that have provided insight into the human condition and serve as an ideal model of translational research. The combination of nonhuman primate behavior, pharmacology and state-of-the-art brain imaging using PET will provide the foundation for future studies aimed at developing behavioral and pharmacological treatments for drug addiction in humans.
本章重点介绍可卡因成瘾的非人类灵长类动物模型的应用，以及正电子发射断层扫描（PET）成像在研究个体易感性差异的作用，以及环境和药理学变量如何影响可卡因滥用方面的应用。本章将描述与多巴胺（DA）神经递质系统相关的研究，并主要关注D2样DA受体、DA转运体以及使用氟脱氧葡萄糖来更好地理解可卡因滥用的神经药理学。使用非人类灵长类动物可以进行个体内纵向研究，这些研究为了解人类情况提供了见解，并作为转化研究的理想模型。将非人类灵长类动物行为、药理学与PET先进脑成像技术相结合，将为未来旨在开发人类药物成瘾行为和药物治疗方法的研究奠定基础。
