Gould Robert W, Duke Angela N, Nader Michael A
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1083, USA.
Neuropharmacology. 2014 Sep;84:138-51. doi: 10.1016/j.neuropharm.2013.02.004. Epub 2013 Feb 28.
The current review highlights the utility of positron emission tomography (PET) imaging to study the neurobiological substrates underlying vulnerability to cocaine addiction and subsequent adaptations following chronic cocaine self-administration in nonhuman primate models of cocaine abuse. Environmental (e.g., social rank) and sex-specific influences on dopaminergic function and sensitivity to the reinforcing effects of cocaine are discussed. Cocaine-related cognitive deficits have been hypothesized to contribute to high rates of relapse and are described in nonhuman primate models. Lastly, the long-term consequences of cocaine on neurobiology are discussed. PET imaging and longitudinal, within-subject behavioral studies in nonhuman primates have provided a strong framework for designing pharmacological and behavioral treatment strategies to aid drug-dependent treatment seekers. Non-invasive PET imaging will allow for individualized treatment strategies. Recent advances in radiochemistry of novel PET ligands and other imaging modalities can further advance our understanding of stimulant use on the brain. This article is part of the Special Issue Section entitled 'Neuroimaging in Neuropharmacology'.
当前的综述强调了正电子发射断层扫描（PET）成像在研究可卡因成瘾易感性的神经生物学基础以及在可卡因滥用的非人类灵长类动物模型中慢性可卡因自我给药后的后续适应性方面的作用。讨论了环境（如社会等级）和性别特异性对多巴胺能功能以及对可卡因强化作用敏感性的影响。可卡因相关的认知缺陷被认为是导致高复发率的原因，并在非人类灵长类动物模型中进行了描述。最后，讨论了可卡因对神经生物学的长期影响。PET成像以及非人类灵长类动物的纵向、个体内行为研究为设计药物和行为治疗策略以帮助寻求药物依赖治疗的人提供了一个强大的框架。非侵入性PET成像将允许采用个性化治疗策略。新型PET配体放射化学及其他成像方式的最新进展能够进一步推进我们对兴奋剂对大脑作用的理解。本文是名为“神经药理学中的神经成像”特刊部分的一篇文章。
