• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Toll-8/Tollo 负调控果蝇呼吸上皮的抗菌反应。

Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium.

机构信息

IBDML, UMR 6216 CNRS, Université Aix-Marseille, Marseille, France.

出版信息

PLoS Pathog. 2011 Oct;7(10):e1002319. doi: 10.1371/journal.ppat.1002319. Epub 2011 Oct 13.

DOI:10.1371/journal.ppat.1002319
PMID:22022271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3192845/
Abstract

Barrier epithelia that are persistently exposed to microbes have evolved potent immune tools to eliminate such pathogens. If mechanisms that control Drosophila systemic responses are well-characterized, the epithelial immune responses remain poorly understood. Here, we performed a genetic dissection of the cascades activated during the immune response of the Drosophila airway epithelium i.e. trachea. We present evidence that bacteria induced-antimicrobial peptide (AMP) production in the trachea is controlled by two signalling cascades. AMP gene transcription is activated by the inducible IMD pathway that acts non-cell autonomously in trachea. This IMD-dependent AMP activation is antagonized by a constitutively active signalling module involving the receptor Toll-8/Tollo, the ligand Spätzle2/DNT1 and Ect-4, the Drosophila ortholog of the human Sterile alpha and HEAT/ARMadillo motif (SARM). Our data show that, in addition to Toll-1 whose function is essential during the systemic immune response, Drosophila relies on another Toll family member to control the immune response in the respiratory epithelium.

摘要

持续暴露于微生物的屏障上皮已经进化出强大的免疫工具来消除这些病原体。如果控制果蝇全身反应的机制得到很好的描述，那么上皮免疫反应仍然知之甚少。在这里，我们对果蝇气道上皮（即气管）免疫反应中激活的级联进行了遗传剖析。我们提供的证据表明，细菌诱导的抗菌肽 (AMP) 在气管中的产生受两个信号级联控制。AMP 基因转录由诱导型 IMD 途径激活，该途径在气管中非自主作用。这种 IMD 依赖性 AMP 激活被涉及受体 Toll-8/Tollo、配体 Spätzle2/DNT1 和 Ect-4（人类无菌α和 HEAT/ARMadillo 基序 (SARM) 的果蝇同源物）的组成性激活信号模块拮抗。我们的数据表明，除了在全身免疫反应中必不可少的 Toll-1 之外，果蝇还依赖于另一个 Toll 家族成员来控制呼吸上皮的免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e7/3192845/cd61ce7ffe16/ppat.1002319.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e7/3192845/62da4a255a62/ppat.1002319.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e7/3192845/6077b5132d74/ppat.1002319.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e7/3192845/39929e8fdcab/ppat.1002319.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e7/3192845/f930ab39a7c2/ppat.1002319.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e7/3192845/5cb91a3b1a37/ppat.1002319.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e7/3192845/cd61ce7ffe16/ppat.1002319.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e7/3192845/62da4a255a62/ppat.1002319.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e7/3192845/6077b5132d74/ppat.1002319.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e7/3192845/39929e8fdcab/ppat.1002319.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e7/3192845/f930ab39a7c2/ppat.1002319.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e7/3192845/5cb91a3b1a37/ppat.1002319.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e7/3192845/cd61ce7ffe16/ppat.1002319.g006.jpg

相似文献

1
Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium.Toll-8/Tollo 负调控果蝇呼吸上皮的抗菌反应。
PLoS Pathog. 2011 Oct;7(10):e1002319. doi: 10.1371/journal.ppat.1002319. Epub 2011 Oct 13.
2
Transcription factor zfh1 downregulates Drosophila Imd pathway.转录因子 Zfh1 下调果蝇 Imd 通路。
Dev Comp Immunol. 2013 Mar;39(3):188-97. doi: 10.1016/j.dci.2012.10.007. Epub 2012 Nov 23.
3
Functional characterization of the infection-inducible peptide Edin in Drosophila melanogaster.果蝇感染诱导肽 Edin 的功能特征。
PLoS One. 2012;7(5):e37153. doi: 10.1371/journal.pone.0037153. Epub 2012 May 14.
4
Regulators of the Toll and Imd pathways in the Drosophila innate immune response.果蝇先天免疫反应中Toll和Imd信号通路的调节因子
Trends Immunol. 2005 Apr;26(4):193-8. doi: 10.1016/j.it.2005.02.006.
5
Ex vivo genome-wide RNAi screening of the Drosophila Toll signaling pathway elicited by a larva-derived tissue extract.利用幼虫来源的组织提取物对果蝇Toll信号通路进行全基因组RNA干扰的体外筛选。
Biochem Biophys Res Commun. 2015 Nov 13;467(2):400-6. doi: 10.1016/j.bbrc.2015.09.138. Epub 2015 Sep 30.
6
Drosophila H2Av negatively regulates the activity of the IMD pathway via facilitating Relish SUMOylation.果蝇 H2Av 通过促进 Relish 的 SUMO 化来负调控 IMD 途径的活性。
PLoS Genet. 2021 Aug 9;17(8):e1009718. doi: 10.1371/journal.pgen.1009718. eCollection 2021 Aug.
7
Ingestion of killed bacteria activates antimicrobial peptide genes in Drosophila melanogaster and protects flies from septic infection.摄入已死亡的细菌会激活黑腹果蝇中的抗菌肽基因，并保护果蝇免受败血症感染。
Dev Comp Immunol. 2019 Jun;95:10-18. doi: 10.1016/j.dci.2019.02.001. Epub 2019 Feb 4.
8
Induction and Suppression of NF-κB Signalling by a DNA Virus of .一种 DNA 病毒对 NF-κB 信号的诱导和抑制。
J Virol. 2019 Jan 17;93(3). doi: 10.1128/JVI.01443-18. Print 2019 Feb 1.
9
Drosophila immunity: methods for monitoring the activity of Toll and Imd signaling pathways.果蝇免疫：监测Toll和Imd信号通路活性的方法
Methods Mol Biol. 2008;415:379-94. doi: 10.1007/978-1-59745-570-1_22.
10
Toll family members bind multiple Spätzle proteins and activate antimicrobial peptide gene expression in .Toll 家族成员结合多个 Spätzle 蛋白并激活. 中的抗菌肽基因表达。
J Biol Chem. 2019 Jun 28;294(26):10172-10181. doi: 10.1074/jbc.RA118.006804. Epub 2019 May 14.

引用本文的文献

1
Toll-9 elicits antiviral immunity against Drosophila C virus.Toll-9引发针对果蝇C病毒的抗病毒免疫。
J Virol. 2025 May 14:e0221424. doi: 10.1128/jvi.02214-24.
2
The molecular toll pathway repertoire in anopheline mosquitoes.按蚊中的分子 toll 途径基因库。
Dev Comp Immunol. 2025 Jan;162:105287. doi: 10.1016/j.dci.2024.105287. Epub 2024 Nov 8.
3
The Molecular Toll Pathway Repertoire in Anopheline Mosquitoes.按蚊中的分子Toll信号通路基因库

本文引用的文献

1
Lack of an antibacterial response defect in Drosophila Toll-9 mutant.果蝇 Toll-9 突变体缺乏抗菌反应缺陷。
PLoS One. 2011 Feb 28;6(2):e17470. doi: 10.1371/journal.pone.0017470.
2
Sugar-free frosting, a homolog of SAD kinase, drives neural-specific glycan expression in the Drosophila embryo.无糖糖霜，SAD 激酶的同源物，驱动果蝇胚胎中神经特异性聚糖的表达。
Development. 2011 Feb;138(3):553-63. doi: 10.1242/dev.055376.
3
Functional analysis of Toll-related genes in Drosophila.果蝇中 Toll 相关基因的功能分析。
bioRxiv. 2024 Sep 18:2024.09.12.612760. doi: 10.1101/2024.09.12.612760.
4
The Potential Biological Roles of Circular RNAs in the Immune Systems of Insects to Pathogen Invasion.环状 RNA 在昆虫免疫系统应对病原体入侵中的潜在生物学作用。
Genes (Basel). 2023 Apr 12;14(4):895. doi: 10.3390/genes14040895.
5
Acute oral toxicity, apoptosis, and immune response in nurse bees () induced by flupyradifurone.氟吡呋喃酮对哺育蜂的急性经口毒性、细胞凋亡及免疫反应
Front Physiol. 2023 Mar 28;14:1150340. doi: 10.3389/fphys.2023.1150340. eCollection 2023.
6
Adult and Larval Tracheal Systems Exhibit Different Molecular Architectures in .成人和幼体气管系统在. 中表现出不同的分子结构。
Int J Mol Sci. 2023 Mar 15;24(6):5628. doi: 10.3390/ijms24065628.
7
modulates JAK/STAT pathway and protects flies against C virus infection.调节 JAK/STAT 通路，保护果蝇免受 C 病毒感染。
Front Immunol. 2023 Feb 3;14:1135625. doi: 10.3389/fimmu.2023.1135625. eCollection 2023.
8
is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration.由衰老和神经退行性变诱导，以调节应激信号，其缺乏会加剧tau介导的神经退行性变。
iScience. 2023 Jan 13;26(2):105968. doi: 10.1016/j.isci.2023.105968. eCollection 2023 Feb 17.
9
The role of micro RNAs (miRNAs) in the regulation of 's innate immunity.微小 RNA（miRNAs）在调控固有免疫中的作用。
Fly (Austin). 2022 Dec;16(1):382-396. doi: 10.1080/19336934.2022.2149204.
10
The circular RNA Edis regulates neurodevelopment and innate immunity.环状 RNA Edis 调控神经发育和先天免疫。
PLoS Genet. 2022 Oct 27;18(10):e1010429. doi: 10.1371/journal.pgen.1010429. eCollection 2022 Oct.
Dev Growth Differ. 2010 Dec;52(9):771-83. doi: 10.1111/j.1440-169X.2010.01213.x.
4
Pipe-dependent ventral processing of Easter by Snake is the defining step in Drosophila embryo DV axis formation.Easter 在果蝇胚胎 DV 轴形成中，依赖于管的腹侧处理是 Snake 定义的步骤。
Curr Biol. 2010 Jun 22;20(12):1133-7. doi: 10.1016/j.cub.2010.04.056. Epub 2010 Jun 3.
5
Amphioxus SARM involved in neural development may function as a suppressor of TLR signaling.文昌鱼 SARM 参与神经发育，可能作为 TLR 信号的抑制因子发挥作用。
J Immunol. 2010 Jun 15;184(12):6874-81. doi: 10.4049/jimmunol.0903675. Epub 2010 May 14.
6
Chronic activation of the epithelial immune system of the fruit fly's salivary glands has a negative effect on organismal growth and induces a peculiar set of target genes.果蝇唾液腺上皮免疫系统的慢性激活对机体的生长有负面影响，并诱导一组特殊的靶基因。
BMC Genomics. 2010 Apr 26;11:265. doi: 10.1186/1471-2164-11-265.
7
Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration.上皮管的形态发生：对管形成、伸长和细化的深入了解。
Dev Biol. 2010 May 1;341(1):34-55. doi: 10.1016/j.ydbio.2009.09.024. Epub 2009 Sep 22.
8
Toll-like receptors and innate immunity.Toll样受体与天然免疫
Biochem Biophys Res Commun. 2009 Oct 30;388(4):621-5. doi: 10.1016/j.bbrc.2009.08.062. Epub 2009 Aug 15.
9
A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway.一种单一的模块化丝氨酸蛋白酶整合来自果蝇Toll信号通路上游模式识别受体的信号。
Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12442-7. doi: 10.1073/pnas.0901924106. Epub 2009 Jul 9.
10
Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes.果蝇IKK复合物在激活Relish及诱导抗菌肽基因表达中的双重作用。
Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9779-84. doi: 10.1073/pnas.0812022106. Epub 2009 Jun 2.