Toews Lorraine
University of Cagary, Health Sciences Library, Calgary, Alberty.
J Vet Med Educ. 2011 Summer;38(2):123-34. doi: 10.3138/jvme.38.2.123.
In human medicine, the information infrastructure that supports the knowledge translation processes of exchange, synthesis, dissemination, and application of the best clinical intervention research has developed significantly in the past 15 years, facilitating the uptake of research evidence by clinicians as well as the practice of evidence-based medicine. Seven of the key elements of this improved information infrastructure are clinical trial registries, research reporting standards, systematic reviews, organizations that support the production of systematic reviews, the indexing of clinical intervention research in MEDLINE, clinical search filters for MEDLINE, and point-of-care decision support information resources. The objective of this paper is to describe why these elements are important for evidence-based medicine, the key developments and issues related to these seven information infrastructure elements in human medicine, how these 7 elements compare with the corresponding infrastructure elements in veterinary medicine, and how all of these factors affect the translation of clinical intervention research into clinical practice. A focused search of the Ovid MEDLINE database was conducted for English language journal literature published between 2000 and 2010. Two bibliographies were consulted and selected national and international Web sites were searched using Google. The literature reviewed indicates that the information infrastructure supporting evidence-based veterinary medicine practice in all of the 7 elements reviewed is significantly underdeveloped in relation to the corresponding information infrastructure in human medicine. This lack of development creates barriers to the timely translation of veterinary medicine research into clinical practice and also to the conduct of both primary clinical intervention research and synthesis research.
在人类医学领域，支持最佳临床干预研究的交流、综合、传播及应用等知识转化过程的信息基础设施，在过去15年中有了显著发展，促进了临床医生对研究证据的采用以及循证医学的实践。这一改进后的信息基础设施的七个关键要素包括临床试验注册库、研究报告标准、系统评价、支持系统评价制作的组织、MEDLINE中临床干预研究的索引、MEDLINE的临床检索过滤器以及即时护理决策支持信息资源。本文的目的是描述这些要素为何对循证医学很重要，人类医学中与这七个信息基础设施要素相关的关键发展和问题，这七个要素与兽医学中相应的基础设施要素相比情况如何，以及所有这些因素如何影响临床干预研究向临床实践的转化。对Ovid MEDLINE数据库进行了重点检索，查找2000年至2010年发表的英文期刊文献。查阅了两份参考文献目录，并使用谷歌搜索了选定的国家和国际网站。所审查的文献表明，与人类医学中相应的信息基础设施相比，在所审查的所有七个要素中，支持循证兽医学实践的信息基础设施明显欠发达。这种发展不足为兽医学研究及时转化为临床实践以及开展初级临床干预研究和综合研究都带来了障碍。
