肺癌伴杵状指患者中前列腺素 E2 水平升高。
Elevation of prostaglandin E2 in lung cancer patients with digital clubbing.
机构信息
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.
出版信息
J Thorac Oncol. 2012 Dec;7(12):1877-1878. doi: 10.1097/JTO.0b013e3181fc76a9.
Abstract
To test the hypothesis that digital clubbing in patients with lung cancer reflects elevated systemic levels of prostaglandin E2 (PGE2), we quantified levels of the major urinary PGE2 metabolite in 29 patients with lung cancer with or without clubbing. We found that digital clubbing was associated with markedly elevated urinary levels of PGE2 metabolite. These findings highlight a potential role for PGE2 in the pathogenesis of digital clubbing. Furthermore, this result identifies a lung cancer subpopulation that may uniquely benefit from cyclooxygenase inhibition.
摘要
为了验证这样一个假说，即肺癌患者的杵状指反映了前列腺素 E2（PGE2）的全身性水平升高，我们对 29 例有或无杵状指的肺癌患者的主要尿 PGE2 代谢产物水平进行了定量分析。我们发现，杵状指与明显升高的尿 PGE2 代谢产物水平相关。这些发现强调了 PGE2 在杵状指发病机制中的潜在作用。此外，这一结果确定了一个肺癌亚群，可能会从环氧化酶抑制中获得独特的益处。
相似文献
1
Elevation of prostaglandin E2 in lung cancer patients with digital clubbing.肺癌伴杵状指患者中前列腺素 E2 水平升高。
J Thorac Oncol. 2012 Dec;7(12):1877-1878. doi: 10.1097/JTO.0b013e3181fc76a9.
2
[Pulmonary hypertrophic osteoarthropathy and clubbing of fingers in patients with lung cancer].[肺癌患者的肺性肥大性骨关节病与杵状指]
Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Oct;33(10):1080-5.
3
[Secondary hypertrophic osteoarthropathy to lung cancer: a case report].[肺癌继发肥大性骨关节病：一例报告]
Rev Port Pneumol. 2009 Jul-Aug;15(4):705-11.
4
Digital clubbing.杵状指
Circulation. 2013 May 14;127(19):1997-9. doi: 10.1161/CIRCULATIONAHA.112.000163.
5
Digital clubbing and lung cancer.杵状指与肺癌
Chest. 1998 Dec;114(6):1535-7. doi: 10.1378/chest.114.6.1535.
6
Prevalence of digital clubbing in bronchogenic carcinoma by a new digital index.通过一种新的数字指数评估支气管肺癌中杵状指的患病率。
Clin Exp Rheumatol. 1998 Jan-Feb;16(1):21-6.
7
[Quantification of finger clubbing].[杵状指的量化]
Presse Med. 2008 Oct;37(10):1520-1. doi: 10.1016/j.lpm.2008.06.012. Epub 2008 Sep 5.
8
Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance.前列腺素转运蛋白基因SLCO2A1中的失活突变，与家族性杵状指、结肠肿瘤和非甾体抗炎药耐药相关。
Cancer Prev Res (Phila). 2014 Aug;7(8):805-12. doi: 10.1158/1940-6207.CAPR-14-0108. Epub 2014 May 16.
9
Hepatocyte growth factor and digital clubbing.
Intern Med. 1997 Jan;36(1):44-6. doi: 10.2169/internalmedicine.36.44.
10
Clubbing: a tipoff to underlying disease.杵状指：潜在疾病的一个提示。
Geriatrics. 1998 Dec;53(12):54-7.
引用本文的文献
1
Pierre-Marie Bamberger Syndrome Leading to the Diagnosis and Surgical Treatment of a Localized Lung Cancer.皮埃尔-玛丽·班贝格综合征导致局限性肺癌的诊断及外科治疗
Cureus. 2023 Nov 18;15(11):e48991. doi: 10.7759/cureus.48991. eCollection 2023 Nov.
2
Digital clubbing occurring in intrathoracic Hodgkin lymphoma: A case report.胸腔内霍奇金淋巴瘤伴发的杵状指：一例报告
Medicine (Baltimore). 2019 Dec;98(51):e18388. doi: 10.1097/MD.0000000000018388.
3
Prostaglandin E-Major Urinary Metabolite (PGE-MUM) as a Tumor Marker for Lung Adenocarcinoma.前列腺素E-主要尿代谢物（PGE-MUM）作为肺腺癌的肿瘤标志物
Cancers (Basel). 2019 Jun 3;11(6):768. doi: 10.3390/cancers11060768.
4
Hypertrophic osteoarthropathy mimicking a reactive arthritis: a case report and review of the literature.酷似反应性关节炎的肥厚性骨关节病：一例病例报告及文献复习
BMC Musculoskelet Disord. 2018 May 14;19(1):145. doi: 10.1186/s12891-018-2068-9.
5
Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease.杵状指与间质性肺疾病患者较高的血清KL-6水平及较低的肺功能相关。
Can Respir J. 2018 Jan 23;2018:3640967. doi: 10.1155/2018/3640967. eCollection 2018.
6
Impact of hypertrophic pulmonary osteoarthropathy on patients with lung cancer.肥厚性肺骨关节病对肺癌患者的影响。
Onco Targets Ther. 2017 Oct 25;10:5173-5177. doi: 10.2147/OTT.S139558. eCollection 2017.
7
Cyclooxygenase-2 inhibitors for non-small-cell lung cancer: A phase II trial and literature review.环氧化酶-2抑制剂用于非小细胞肺癌：一项II期试验及文献综述。
Mol Clin Oncol. 2014 Sep;2(5):744-750. doi: 10.3892/mco.2014.319. Epub 2014 Jun 19.
本文引用的文献
1
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy.15-羟基前列腺素脱氢酶突变导致原发性肥大性骨关节病。
Nat Genet. 2008 Jun;40(6):789-93. doi: 10.1038/ng.153. Epub 2008 May 25.
2
Novel strategies for the treatment of lung cancer: modulation of eicosanoids.肺癌治疗的新策略：类花生酸的调节
J Clin Oncol. 2008 Feb 20;26(6):825-7. doi: 10.1200/JCO.2007.14.9583.
3
Hypertrophic osteoarthropathy pathogenesis: a case highlighting the potential role for cyclo-oxygenase-2-derived prostaglandin E2.
Nat Clin Pract Rheumatol. 2006 Aug;2(8):452-6; quiz following 456. doi: 10.1038/ncprheum0252.
4
Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer.通过液相色谱/质谱分析法对PGE2主要尿代谢物进行定量：测定健康人和肺癌患者中环氧合酶特异性PGE2的合成。
Anal Biochem. 2004 Nov 15;334(2):266-75. doi: 10.1016/j.ab.2004.08.019.
5
Cortical hyperostosis following long-term administration of prostaglandin E1 in infants with cyanotic congenital heart disease.患有青紫型先天性心脏病的婴儿长期使用前列腺素E1后出现皮质骨增生。
J Pediatr. 1980 Nov;97(5):834-6. doi: 10.1016/s0022-3476(80)80282-4.
6
Personal experience.个人经历。
S Afr Med J. 1976 Feb 28;50(9):297-300.
Zotero 插件