Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.
J Thorac Oncol. 2012 Dec;7(12):1877-1878. doi: 10.1097/JTO.0b013e3181fc76a9.
To test the hypothesis that digital clubbing in patients with lung cancer reflects elevated systemic levels of prostaglandin E2 (PGE2), we quantified levels of the major urinary PGE2 metabolite in 29 patients with lung cancer with or without clubbing. We found that digital clubbing was associated with markedly elevated urinary levels of PGE2 metabolite. These findings highlight a potential role for PGE2 in the pathogenesis of digital clubbing. Furthermore, this result identifies a lung cancer subpopulation that may uniquely benefit from cyclooxygenase inhibition.
为了验证这样一个假说,即肺癌患者的杵状指反映了前列腺素 E2(PGE2)的全身性水平升高,我们对 29 例有或无杵状指的肺癌患者的主要尿 PGE2 代谢产物水平进行了定量分析。我们发现,杵状指与明显升高的尿 PGE2 代谢产物水平相关。这些发现强调了 PGE2 在杵状指发病机制中的潜在作用。此外,这一结果确定了一个肺癌亚群,可能会从环氧化酶抑制中获得独特的益处。