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Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy.15-羟基前列腺素脱氢酶突变导致原发性肥大性骨关节病。
Nat Genet. 2008 Jun;40(6):789-93. doi: 10.1038/ng.153. Epub 2008 May 25.
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Novel strategies for the treatment of lung cancer: modulation of eicosanoids.肺癌治疗的新策略：类花生酸的调节
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Hypertrophic osteoarthropathy pathogenesis: a case highlighting the potential role for cyclo-oxygenase-2-derived prostaglandin E2.
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Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer.通过液相色谱/质谱分析法对PGE2主要尿代谢物进行定量：测定健康人和肺癌患者中环氧合酶特异性PGE2的合成。
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5
Cortical hyperostosis following long-term administration of prostaglandin E1 in infants with cyanotic congenital heart disease.患有青紫型先天性心脏病的婴儿长期使用前列腺素E1后出现皮质骨增生。
J Pediatr. 1980 Nov;97(5):834-6. doi: 10.1016/s0022-3476(80)80282-4.
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Personal experience.个人经历。
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肺癌伴杵状指患者中前列腺素 E2 水平升高。

Elevation of prostaglandin E2 in lung cancer patients with digital clubbing.

机构信息

Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.

出版信息

J Thorac Oncol. 2012 Dec;7(12):1877-1878. doi: 10.1097/JTO.0b013e3181fc76a9.

DOI:10.1097/JTO.0b013e3181fc76a9
PMID:22024643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3371124/
Abstract

To test the hypothesis that digital clubbing in patients with lung cancer reflects elevated systemic levels of prostaglandin E2 (PGE2), we quantified levels of the major urinary PGE2 metabolite in 29 patients with lung cancer with or without clubbing. We found that digital clubbing was associated with markedly elevated urinary levels of PGE2 metabolite. These findings highlight a potential role for PGE2 in the pathogenesis of digital clubbing. Furthermore, this result identifies a lung cancer subpopulation that may uniquely benefit from cyclooxygenase inhibition.

摘要

为了验证这样一个假说，即肺癌患者的杵状指反映了前列腺素 E2（PGE2）的全身性水平升高，我们对 29 例有或无杵状指的肺癌患者的主要尿 PGE2 代谢产物水平进行了定量分析。我们发现，杵状指与明显升高的尿 PGE2 代谢产物水平相关。这些发现强调了 PGE2 在杵状指发病机制中的潜在作用。此外，这一结果确定了一个肺癌亚群，可能会从环氧化酶抑制中获得独特的益处。