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[一名T细胞隐蔽抗原释放的成年患者的溶血尿毒综合征]

[Hemolytic-uremic syndrome in an adult with T-cryptantigen liberation].

作者信息

Rumpf K W, Lynen R, Verwiebe R, Schilling H, Neumeyer H

机构信息

Abteilung Nephrologie und Rheumatologie, Universität Göttingen.

出版信息

Dtsch Med Wochenschr. 1990 Aug 24;115(34):1270-5. doi: 10.1055/s-2008-1065152.

Abstract

Haemolytic uraemic syndrome was diagnosed in a 36-year-old woman with acute renal failure (creatinine 10.5 mg/dl), haemolytic anaemia (haemoglobin 9.7 g/dl, lactate dehydrogenase 1926 U/l) and thrombopenia (98,000/microliters). After initial plasmaphereses and high doses of furosemide all symptoms disappeared within three weeks. The lectin tests demonstrated that the illness was connected with the liberation of T-crypt-antigen (Thomsen-Friedenreich antigen) on the erythrocytes. This special form of the haemolytic uraemic syndrome (neuraminidase-induced haemolytic uraemic syndrome) has previously been observed almost exclusively in children. However, for diagnosis and differentiation of haemolytic uraemic syndromes the presence of liberated T-antigen on erythrocytes should also be tested for in adults.

摘要

一名36岁女性被诊断为溶血性尿毒症综合征,伴有急性肾衰竭(肌酐10.5毫克/分升)、溶血性贫血(血红蛋白9.7克/分升,乳酸脱氢酶1926国际单位/升)和血小板减少症(98,000/微升)。在最初进行血浆置换和大剂量使用速尿后,所有症状在三周内消失。凝集素试验表明,该疾病与红细胞上T-隐抗原(汤姆森-弗里德赖希抗原)的释放有关。这种特殊形式的溶血性尿毒症综合征(神经氨酸酶诱导的溶血性尿毒症综合征)此前几乎仅在儿童中观察到。然而,对于溶血性尿毒症综合征的诊断和鉴别,成人也应检测红细胞上是否存在释放的T抗原。

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