Hasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
NIH, Dept. of Laboratory Medicine, Clinical Center, Bethesda, United States.
Sci Rep. 2017 Feb 23;7:43410. doi: 10.1038/srep43410.
Lipoproteins modulate innate and adaptive immune responses. In the chronic inflammatory disease multiple sclerosis (MS), reports on lipoprotein level alterations are inconsistent and it is unclear whether lipoprotein function is affected. Using nuclear magnetic resonance (NMR) spectroscopy, we analysed the lipoprotein profile of relapsing-remitting (RR) MS patients, progressive MS patients and healthy controls (HC). We observed smaller LDL in RRMS patients compared to healthy controls and to progressive MS patients. Furthermore, low-BMI (BMI ≤ 23 kg/m) RRMS patients show increased levels of small HDL (sHDL), accompanied by larger, triglyceride (TG)-rich VLDL, and a higher lipoprotein insulin resistance (LP-IR) index. These alterations coincide with a reduced serum capacity to accept cholesterol via ATP-binding cassette (ABC) transporter G1, an impaired ability of HDL to suppress inflammatory activity of human monocytes, and modifications of HDL's main protein component ApoA-I. In summary, lipoprotein levels and function are altered in RRMS patients, especially in low-BMI patients, which may contribute to disease progression in these patients.
脂蛋白调节先天和适应性免疫反应。在慢性炎症性疾病多发性硬化症（MS）中，关于脂蛋白水平变化的报告不一致，也不清楚脂蛋白功能是否受到影响。我们使用核磁共振（NMR）光谱分析了复发缓解型（RR）MS 患者、进行性 MS 患者和健康对照（HC）的脂蛋白谱。与健康对照组和进行性 MS 患者相比，我们观察到 RRMS 患者的 LDL 较小。此外，低体重指数（BMI≤23kg/m）RRMS 患者表现出小高密度脂蛋白（sHDL）水平升高，伴有更大的富含甘油三酯（TG）的 VLDL 和更高的脂蛋白胰岛素抵抗（LP-IR）指数。这些变化与血清通过 ATP 结合盒（ABC）转运蛋白 G1 接受胆固醇的能力降低、HDL 抑制人单核细胞炎症活性的能力受损以及 HDL 主要蛋白成分 ApoA-I 的修饰相一致。总之，RRMS 患者的脂蛋白水平和功能发生改变，尤其是低 BMI 患者，这可能导致这些患者的疾病进展。
