Saha A, Barman I, Dingari N C, McGee S, Volynskaya Z, Galindo L H, Liu W, Plecha D, Klein N, Dasari R R, Fitzmaurice M
Biomed Opt Express. 2011 Oct 1;2(10):2792-803. doi: 10.1364/BOE.2.002792. Epub 2011 Sep 14.
Microcalcifications are an early mammographic sign of breast cancer and a target for stereotactic breast needle biopsy. We present here a Raman spectroscopic tool for detecting microcalcifications in breast tissue based on their chemical composition. We collected ex vivo Raman spectra from 159 tissue sites in fresh stereotactic breast needle biopsies from 33 patients, including 54 normal sites, 75 lesions with microcalcifications and 30 lesions without microcalcifications. Application of our Raman technique resulted in a positive predictive value of 97% for detecting microcalcifications. This study shows that Raman spectroscopy has the potential to detect microcalcifications during stereotactic breast core biopsies and provide real-time feedback to radiologists, thus reducing non-diagnostic and false negative biopsies.
微钙化是乳腺癌的早期乳腺X线征象，也是立体定向乳腺针吸活检的目标。我们在此展示一种基于化学成分检测乳腺组织中微钙化的拉曼光谱工具。我们从33例患者的新鲜立体定向乳腺针吸活检的159个组织部位收集了离体拉曼光谱，包括54个正常部位、75个有微钙化的病变部位和30个无微钙化的病变部位。我们的拉曼技术应用于检测微钙化的阳性预测值为97%。这项研究表明，拉曼光谱有潜力在立体定向乳腺粗针活检过程中检测微钙化，并向放射科医生提供实时反馈，从而减少非诊断性和假阴性活检。
