Sánchez-Orgaz Margarita, Grabowska Anna, Royo-Oreja Arantza, Asencio-Durán Mónica, Romero-Martín Ricardo, Arbizu-Duralde Alvaro
Ophthalmology Service, University Hospital La Paz, Paseo Castellana 261, Madrid, Spain.
Orbit. 2012 Feb;31(1):30-3. doi: 10.3109/01676830.2011.603458. Epub 2011 Oct 26.
Radiation optic neuropathy (RON) is a devastating complication of radiotherapy to the anterior visual pathway resulting in acute, profound and sometimes irreversible visual loss. Cumulative doses of radiation that exceed 50 Gy or radiation fractions of greater than 2 Gy are usually required for RON to develop. Several factors, such as diabetes and pre-existing compression of the optic nerve, are associated with a higher risk for developing RON at lower doses of radiation. We report a case of presumed subacute RON following orbital irradiation for Graves' ophthalmopathy, successfully treated with megadoses of intravenous corticosteroids.
放射性视神经病变（RON）是前视觉通路放疗的一种毁灭性并发症，可导致急性、严重且有时不可逆的视力丧失。RON的发生通常需要超过50 Gy的累积辐射剂量或大于2 Gy的分次辐射剂量。糖尿病和既往存在的视神经受压等多种因素与较低辐射剂量下发生RON的较高风险相关。我们报告1例因格雷夫斯眼病行眼眶照射后疑似亚急性RON的病例，经大剂量静脉注射皮质类固醇成功治疗。
