DeLany J P, Vivian V M, Snook J T, Anderson P A
Department of Human Nutrition and Food Management, Ohio State University, Columbus 43210.
Am J Clin Nutr. 1990 Sep;52(3):477-85. doi: 10.1093/ajcn/52.3.477.
Effects of fish-oil (FO) feeding on serum lipids were investigated in a 42-d controlled diet study. Fifteen healthy male college students were assigned to one of three groups: control (0 g FO); 5 g FO, supplying 2 g n - 3 (omega-3) fatty acids (FAs); or 20 g FO, supplying 8 g n - 3 FAs. In an initial 7-d period subjects consumed a basal diet with no FO. Then FO replaced an equivalent amount of margarine for 5 wk. FO feeding significantly (p less than 0.05) decreased the serum n - 6 FAs, linoleic acid, eicosatrienoic acid, and arachidonic acid. A significant increase in the n - 3 FAs, eicosapentaenoic acid and docosahexaenoic acid, was noted in serum, platelet, and neutrophil phospholipids. The 20-g-FO group showed a 30% decrease (p less than 0.01) in triglycerides after 2 wk FO with no further decrease observed. Thus, 20 g FO produced changes in both FA patterns and triglyceride concentrations whereas 5 g FO produced changes in FA patterns only. Neither FO amount resulted in significant changes in total or HDL cholesterol, apolipoprotein A-I, or apolipoprotein B-100.
在一项为期42天的对照饮食研究中，研究了鱼油（FO）喂养对血清脂质的影响。15名健康男性大学生被分配到三组中的一组：对照组（0克FO）；5克FO，提供2克n-3（ω-3）脂肪酸（FAs）；或20克FO，提供8克n-3 FAs。在最初的7天里，受试者食用不含FO的基础饮食。然后，FO替代等量的人造黄油，持续5周。FO喂养显著（p<0.05）降低了血清n-6 FAs、亚油酸、二十碳三烯酸和花生四烯酸。在血清、血小板和中性粒细胞磷脂中，n-3 FAs、二十碳五烯酸和二十二碳六烯酸显著增加。20克FO组在FO喂养2周后甘油三酯降低了30%（p<0.01），之后未观察到进一步降低。因此，20克FO使FA模式和甘油三酯浓度均发生变化，而5克FO仅使FA模式发生变化。两种FO用量均未导致总胆固醇或高密度脂蛋白胆固醇、载脂蛋白A-I或载脂蛋白B-100发生显著变化。
