Green S M, Johnson N E
Department of Emergency Medicine, Riverside General Hospital, California 92503.
Ann Emerg Med. 1990 Sep;19(9):1033-46. doi: 10.1016/s0196-0644(05)82569-7.
Ketamine produces rapid and consistent pediatric sedation with a predictable onset and recovery time. A wide margin of safety is afforded without the respiratory and cardiovascular depression commonly seen with alternative agents. The efficacy of ketamine is well established in anesthesia and dentistry and has extensive applications in other specialties. Ketamine sedation facilitates superior technical and cosmetic results while minimizing emotional trauma to distraught children. The much-feared complications of aspiration and laryngospasm are extremely rare when ketamine is used with proper precautions. Ketamine deserves increased use in the ED, and we advocate additional clinical investigation in this setting.
氯胺酮能迅速且持续地使儿童镇静，起效时间和恢复时间可预测。其具有广泛的安全范围，不会出现其他替代药物常见的呼吸和心血管抑制。氯胺酮在麻醉和牙科领域的疗效已得到充分证实，并且在其他专业领域也有广泛应用。氯胺酮镇静有助于获得更好的技术和美容效果，同时将对心烦意乱的儿童造成的情感创伤降至最低。在采取适当预防措施使用氯胺酮时，令人恐惧的误吸和喉痉挛并发症极为罕见。氯胺酮在急诊科应得到更多应用，我们主张在此背景下开展更多临床研究。
