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澳大利亚心脏起搏史:往昔岁月的回忆

The Australian history of cardiac pacing: memories from a bygone era.

作者信息

Mond Harry G, Wickham Geoffrey G, Sloman J Graeme

机构信息

Department of Cardiology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.

出版信息

Heart Lung Circ. 2012 Jun;21(6-7):311-9. doi: 10.1016/j.hlc.2011.09.004. Epub 2011 Oct 26.

Abstract

Although Dr Albert Hyman in New York is believed to have built the first cardiac pacemaker in 1932, he acknowledges Dr Mark Lidwell in Sydney, Australia as having not only built a pacemaker, but also successfully used it to resuscitate a newborn infant in or before 1929. Fully implantable pacemakers, however, were not possible until 1958, following the development of the silicon transistor. Within three years of that first implant, a pulse generator attached to epicardial leads was implanted at the Royal Melbourne Hospital. About the same time, an engineer in Sydney with intermittent complete heart block who had received epicardial leads and an external pulse generator proposed a simple sensing circuit, leading to the design of the first demand pacing system. By the mid 1960s, physicians were inserting transvenous leads in the right ventricle attached to pulse generators implanted in the anterior abdominal wall. In 1963, an Australian pacemaker company, Telectronics, was founded in Sydney. This innovative company-designed many of the features of transvenous leads and pulse generators we take for granted today. Australia also played a leading role in the design or early evaluation of the lithium power source, lead fixation, steroid elution, automatic anti-tachycardia pacing algorithms and the minute ventilation rate adaptive sensor. This manuscript describes the challenges and frustrations of those pioneers: physicians, surgeons and biomedical engineers.

摘要

尽管人们认为纽约的阿尔伯特·海曼医生在1932年制造了第一台心脏起搏器,但他承认澳大利亚悉尼的马克·利德韦尔医生不仅制造了一台起搏器,还在1929年或之前成功地用它使一名新生儿复苏。然而,直到1958年硅晶体管出现后,完全植入式起搏器才成为可能。在首次植入后的三年内,一个连接着心外膜导线的脉冲发生器被植入了皇家墨尔本医院。大约在同一时间,悉尼的一名患有间歇性完全性心脏传导阻滞的工程师,在接受了心外膜导线和一个外部脉冲发生器后,提出了一个简单的传感电路,从而促成了第一个按需起搏系统的设计。到20世纪60年代中期,医生们开始在右心室插入经静脉导线,并将其连接到植入在前腹壁的脉冲发生器上。1963年,一家澳大利亚起搏器公司——泰莱克tronics在悉尼成立。这家创新型公司设计了许多我们如今视为理所当然的经静脉导线和脉冲发生器的特性。澳大利亚在锂电源、导线固定、类固醇洗脱、自动抗心动过速起搏算法以及分钟通气率自适应传感器的设计或早期评估方面也发挥了主导作用。这篇手稿描述了那些先驱者——医生、外科医生和生物医学工程师所面临的挑战和挫折。

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