Department of Psychiatry, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Biol Psychol. 2012 Jan;89(1):214-9. doi: 10.1016/j.biopsycho.2011.10.012. Epub 2011 Oct 25.
Recent meta-analyses point towards a pathogenic role of the Val66Met variant of the brain-derived neurotrophic factor (BDNF) in major depressive disorder, specifically in males. We investigated whether BDNF Val66Met shows a male-specific interaction with childhood stressful life events on affective memory bias, a cognitive susceptibility factor for depression. Healthy volunteers (n=430; 272 females and 158 males) were genotyped for BDNF Val66Met (rs6265) and completed the self-referent encoding task and a childhood stressful life events scale. BDNF Met carriers reporting childhood events tended to recall a lower proportion of positive words compared to Val/Val homozygotes reporting childhood events. Sex-specific analyses revealed that the BDNF genotype×childhood events interaction was significant in male participants and not in female participants. The results suggest that in males, BDNF Val66Met interacts with childhood life events, increasing the cognitive susceptibility markers of depression. In females, this effect may be independent of BDNF Val66Met.
最近的荟萃分析指出，脑源性神经营养因子（BDNF）的 Val66Met 变体在男性的重度抑郁症中具有致病性作用，特别是在男性中。我们研究了 BDNF Val66Met 是否与童年生活应激事件表现出男性特有的相互作用，而童年生活应激事件是抑郁的认知易感性因素。健康志愿者（n=430；272 名女性和 158 名男性）进行了 BDNF Val66Met（rs6265）基因分型，并完成了自我参照编码任务和童年生活应激事件量表。报告童年事件的 BDNF Met 携带者与报告童年事件的 Val/Val 纯合子相比，倾向于回忆较少的积极词汇。性别特异性分析显示，BDNF 基因型×童年事件的相互作用在男性参与者中显著，而在女性参与者中不显著。结果表明，在男性中，BDNF Val66Met 与童年生活事件相互作用，增加了抑郁的认知易感性标志物。在女性中，这种影响可能独立于 BDNF Val66Met。
