Macdonald Birthe, Murray Lynne, Moutsiana Christina, Fearon Pasco, Cooper Peter J, Halligan Sarah L, Johnstone Tom
Department of Psychology, University of Reading, Whiteknights, Reading RG6 6AL, United Kingdom.
Department of Psychology, University of Reading, Whiteknights, Reading RG6 6AL, United Kingdom; Department of Psychology, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch 7602, South Africa.
Biol Psychol. 2016 Jul;118:147-153. doi: 10.1016/j.biopsycho.2016.05.006. Epub 2016 May 18.
Maternal depression is associated with increased risk for offspring mood and anxiety disorders. One possible impact of maternal depression during offspring development is on the emotional autobiographical memory system. We investigated the neural mechanisms of emotional autobiographical memory in adult offspring of mothers with postnatal depression (N=16) compared to controls (N=21). During fMRI, recordings of participants describing one pleasant and one unpleasant situation with their mother and with a companion, were used as prompts to re-live the situations. Compared to controls we predicted the PND offspring would show: greater activation in medial and posterior brain regions implicated in autobiographical memory and rumination; and decreased activation in lateral prefrontal cortex and decreased connectivity between lateral prefrontal and posterior regions, reflecting reduced control of autobiographical recall. For negative situations, we found no group differences. For positive situations with their mothers, PND offspring showed higher activation than controls in left lateral prefrontal cortex, right frontal pole, cingulate cortex and precuneus, and lower connectivity of right middle frontal gyrus, left middle temporal gyrus, thalamus and lingual gyrus with the posterior cingulate. Our results are consistent with adult offspring of PND mothers having less efficient prefrontal regulation of personally relevant pleasant autobiographical memories.
母亲抑郁与后代出现情绪和焦虑障碍的风险增加有关。母亲抑郁在后代发育过程中的一个可能影响是对情感自传体记忆系统的影响。我们调查了产后抑郁母亲的成年后代（N = 16）与对照组（N = 21）相比，情感自传体记忆的神经机制。在功能磁共振成像（fMRI）期间，参与者描述与母亲和同伴的一个愉快和一个不愉快情境的记录被用作重温这些情境的提示。与对照组相比，我们预测产后抑郁后代会表现出：在内侧和后脑区域有更大的激活，这些区域与自传体记忆和沉思有关；外侧前额叶皮层的激活减少，以及外侧前额叶与后部区域之间的连接性降低，反映出自传体回忆的控制减弱。对于负面情境，我们没有发现组间差异。对于与母亲的正面情境，产后抑郁后代在左侧外侧前额叶皮层、右侧额极、扣带回皮层和楔前叶表现出比对照组更高的激活，并且右侧额中回、左侧颞中回、丘脑和舌回与后扣带回的连接性更低。我们的结果与产后抑郁母亲的成年后代对个人相关的愉快自传体记忆的前额叶调节效率较低一致。
