Levin E G, Miller V T, Muesing R A, Stoy D B, Balm T K, LaRosa J C
Lipid Research Clinic, George Washington Medical Center, Washington, DC 20037.
Arch Intern Med. 1990 Sep;150(9):1822-7.
The effects of the administration of 5.1 g of psyllium or placebo (cellulose) twice daily for 16 weeks were compared as adjuncts to a prudent diet in the management of moderate hypercholesterolemia in a parallel, double-blind study. Psyllium decreased the total cholesterol level by 5.6% and the low-density lipoprotein cholesterol level by 8.6%, whereas the levels were unchanged in the placebo group. The high-density lipoprotein cholesterol level decreased during the diet stabilization period in both groups and returned to near-baseline values by week 16. Plasma triglyceride levels did not change substantially in either group. Subject compliance to treatment was greater than 95%. These data suggest that psyllium hydrophilic mucilloid in a twice-daily regimen may be a useful and safe adjunct to a prudent diet in the treatment of moderate hypercholesterolemia.
在一项平行双盲研究中，比较了每日两次服用5.1克车前草或安慰剂（纤维素），持续16周作为谨慎饮食辅助手段治疗中度高胆固醇血症的效果。车前草使总胆固醇水平降低了5.6%，低密度脂蛋白胆固醇水平降低了8.6%，而安慰剂组的这些水平没有变化。两组的高密度脂蛋白胆固醇水平在饮食稳定期均有所下降，并在第16周时恢复到接近基线值。两组的血浆甘油三酯水平均无显著变化。受试者对治疗的依从性大于95%。这些数据表明，每日两次服用车前草亲水胶浆可能是治疗中度高胆固醇血症时谨慎饮食的一种有用且安全的辅助手段。
