Bell L P, Hectorne K, Reynolds H, Balm T K, Hunninghake D B
Department of Medicine, University of Minnesota, Minneapolis.
JAMA. 1989 Jun 16;261(23):3419-23. doi: 10.1001/jama.261.23.3419.
Psyllium hydrophilic mucilloid was examined for its ability to lower serum cholesterol levels in hypercholesterolemic patients. Seventy-five patients with mild to moderate hypercholesterolemia were evaluated in this randomized, double-blind, placebo-controlled parallel study. Patients were treated with a Step I diet for 12 weeks before receiving placebo or 3.4 g of psyllium (equivalent to 1 teaspoon) three times per day for 8 weeks. Compared with placebo, psyllium achieved an additional 4.8% reduction in total cholesterol level, 8.2% reduction in low-density lipoprotein cholesterol level, and 8.8% reduction in apolipoprotein B level. Psyllium did not significantly affect blood pressure or levels of high-density cholesterol, triglycerides, serum glucose, or iron. Reported adherence to diet and treatment was excellent, and no significant adverse side effects were noted. These results indicate psyllium hydrophilic mucilloid is an effective and well-tolerated adjunct to diet in the management of mild to moderate hypercholesterolemia.
对车前草亲水粘胶降低高胆固醇血症患者血清胆固醇水平的能力进行了研究。在这项随机、双盲、安慰剂对照的平行研究中，对75例轻度至中度高胆固醇血症患者进行了评估。患者在接受安慰剂或每天3次、每次3.4克车前草（相当于1茶匙）治疗8周之前，先采用第一步饮食方案治疗12周。与安慰剂相比，车前草使总胆固醇水平额外降低了4.8%，低密度脂蛋白胆固醇水平降低了8.2%，载脂蛋白B水平降低了8.8%。车前草对血压或高密度胆固醇、甘油三酯、血糖或铁的水平没有显著影响。据报告，患者对饮食和治疗的依从性良好，未发现明显的不良副作用。这些结果表明，车前草亲水粘胶是治疗轻度至中度高胆固醇血症的一种有效且耐受性良好的饮食辅助药物。
