Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary.
Curr Opin Neurobiol. 2012 Jun;22(3):366-71. doi: 10.1016/j.conb.2011.10.006. Epub 2011 Oct 25.
Following the astonishing molecular diversity of voltage-gated ion channels that was revealed in the past few decades, the ion channel repertoire expressed by neurons has been implicated as the major factor governing their functional heterogeneity. Although the molecular structure of ion channels is a key determinant of their biophysical properties, their subcellular distribution and densities on the surface of nerve cells are just as important for fulfilling functional requirements. Recent results obtained with high resolution quantitative localization techniques revealed complex, subcellular compartment-specific distribution patterns of distinct ion channels. Here I suggest that within a given neuron type every ion channel has a unique cell surface distribution pattern, with the functional consequence that this dramatically increases the computational power of nerve cells.
继过去几十年揭示的电压门控离子通道令人惊讶的分子多样性之后，神经元表达的离子通道 repertoire 已被认为是决定其功能异质性的主要因素。尽管离子通道的分子结构是决定其生物物理特性的关键因素，但它们在神经细胞表面的亚细胞分布和密度对于满足功能要求同样重要。最近使用高分辨率定量定位技术获得的结果揭示了不同离子通道的复杂、亚细胞区室特异性分布模式。在这里，我认为在给定的神经元类型中，每个离子通道都具有独特的细胞表面分布模式，其功能后果是，这极大地增加了神经细胞的计算能力。
