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青蒿素:来自传统中药的馈赠,不仅可用于疟疾防控,也可用于血吸虫病防控。

Artemisinin: the gifts from traditional Chinese medicine not only for malaria control but also for schistosomiasis control.

机构信息

Department of Medical Parasitology, School of Basic Medical Science, Wuhan University, 185 East Lake Road, Wuchang, Wuhan, 430071, Hubei Province, China.

出版信息

Parasitol Res. 2012 May;110(5):2071-4. doi: 10.1007/s00436-011-2707-7. Epub 2011 Oct 27.

Abstract

The 2011 Lasker~DeBakey Clinical Medical Research Award honors the Chinese scientist Tu Youyou who discovered artemisinin and its utility for treating malaria. A therapy based on artemisinin has saved millions of lives across the globe, especially in the developing world. Meanwhile, artemisinin and its derivatives, especially for artemether and artesunate, are showing promising preventive efficacies as high as 65-97% administrated with multiple doses at 6 mg/kg body weight by 1- or 2-week intervals for preventing schistosomiasis japonica during epidemic seasons used in China for more than one decade. So, we would like to say, to our excitement, artemisinin and its derivatives are the gifts from traditional Chinese medicine not only for malaria control but also for schistosomiasis control.

摘要

2011 年拉斯克~德贝基临床医学研究奖授予中国科学家屠呦呦,她发现了青蒿素及其在治疗疟疾方面的效用。基于青蒿素的疗法已在全球范围内挽救了数百万人的生命,特别是在发展中国家。与此同时,青蒿素及其衍生物,特别是蒿甲醚和青蒿琥酯,在预防日本血吸虫病方面显示出高达 65-97%的有希望的预防效果,在中国,在流行季节期间,每公斤体重 6 毫克的多剂量间隔 1 或 2 周给药,用于预防日本血吸虫病,已使用了十多年。因此,我们想说,令我们兴奋的是,青蒿素及其衍生物不仅是控制疟疾的中医药馈赠,也是控制血吸虫病的中医药馈赠。

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