EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain.
Curr Opin Biotechnol. 2012 Jun;23(3):305-14. doi: 10.1016/j.copbio.2011.10.004. Epub 2011 Oct 28.
Signal transduction is the process of converting one kind of signal or stimulus into another, with the goal of processing external or internal signals into diverse functions. In recent years, progress has been made in identifying signaling pathways, investigating cross-talk and feedbacks in signaling modules, analyzing cell-type specific signaling, and unraveling spatial-temporal aspects, such as receptor clustering into micro-domains, dynamic localization, and mathematical modeling. Here, we used the receptor/MAPK signaling system as an example, and we discuss the current and remaining challenges: the role of scaffolds and signaling machines, the importance of concentration and competition, the use of structural information, the integration of large-scale proteomic datasets, and the future challenge of integrating alternative splicing into signaling pathways.
信号转导是将一种信号或刺激转化为另一种信号的过程，目的是将外部或内部信号处理为多种功能。近年来，在鉴定信号通路、研究信号模块中的串扰和反馈、分析细胞类型特异性信号以及揭示受体聚类成微域、动态定位和数学建模等时空方面方面取得了进展。在这里，我们以受体/MAPK 信号系统为例，讨论了当前和剩余的挑战：支架和信号机器的作用、浓度和竞争的重要性、结构信息的利用、大规模蛋白质组数据集的整合，以及将选择性剪接纳入信号通路的未来挑战。
