Asselin W M, Caughlin J D
Royal Canadian Mounted Police, Forensic Laboratory, Vancouver, British Columbia.
J Anal Toxicol. 1990 Jul-Aug;14(4):254-5. doi: 10.1093/jat/14.4.254.
Acetylsalicylic acid (ASA) is still one of the most commonly used therapeutic agents. Salicylic acid, the major metabolite of ASA, can be detected easily in urine using simple chemical spot tests such as ferric chloride or Trinder's reagent. In forensic cases, urine is often not available and the rapid detection of salicylate in whole hemolyzed blood can be difficult. This report describes the rapid and simple detection of salicylate using ferric chloride and a methanolic extract of whole blood. The color test is rapid and can detect salicylate at mid-therapeutic concentrations of 5 mg/dL. As little as 300 microL of whole blood is required and no equipment is needed. The color test can also be used with serum or plasma.
乙酰水杨酸（ASA）仍然是最常用的治疗药物之一。水杨酸是ASA的主要代谢产物，使用简单的化学斑点试验，如氯化铁或Trinder试剂，可在尿液中轻松检测到。在法医案件中，通常无法获取尿液，而在全溶血血液中快速检测水杨酸盐可能很困难。本报告描述了使用氯化铁和全血甲醇提取物快速、简单地检测水杨酸盐的方法。该颜色试验快速，可在治疗浓度为5mg/dL时检测出水杨酸盐。只需300微升全血，无需任何设备。该颜色试验也可用于血清或血浆。
