Inoue Daisuke
Third Department of Medicine, Teikyo University Chiba Medical Center, Japan.
Clin Calcium. 2011 Nov;21(11):82-9.
Among various pleiotropic actions of vitamin D, its immunomodulatory role has been well recognized for more than 30 years. However, despite the presence of vitamin D receptors in immune cells including lymphocytes and monocytes/macrorphages, the impact of vitamin D system on immune regulation remained unclear. Recently, two key functions of vitamin D : induction of antimicrobial peptides and autophagy in cells of the monocyte/macrophage lineage, have been described, revealing a much clearer picture of the role of vitamin D as an immunomodulator, particularly in innate immunity against pathogens such as Mycobacterium tuberculosis. This review summarizes recent advances in research of vitamin D as a regulator of innate immunity, and clinical trials of vitamin D as a potential anti-infectious agent.
在维生素D的多种多效性作用中，其免疫调节作用在30多年前就已得到充分认识。然而，尽管在包括淋巴细胞和单核细胞/巨噬细胞在内的免疫细胞中存在维生素D受体，但维生素D系统对免疫调节的影响仍不清楚。最近，已描述了维生素D的两个关键功能：诱导单核细胞/巨噬细胞谱系细胞中的抗菌肽和自噬，这揭示了维生素D作为免疫调节剂的作用，特别是在针对结核分枝杆菌等病原体的固有免疫中的作用，有了更为清晰的认识。本综述总结了维生素D作为固有免疫调节剂的研究进展，以及维生素D作为潜在抗感染剂的临床试验情况。
