Bartley J
Department of Otolaryngology-Head and Neck Surgery, Counties-Manukau District Health Board, Auckland, New Zealand.
J Laryngol Otol. 2010 May;124(5):465-9. doi: 10.1017/S0022215109992684. Epub 2010 Jan 13.
At the turn of the twentieth century, ultraviolet light was successfully used to treat tuberculosis of the skin. Upper respiratory tract infections had been inversely associated with sun exposure. During the last decade, basic scientific research demonstrated that vitamin D has an important anti-infective role.
Review of the relevant literature on the influence of vitamin D on innate immunity and respiratory tract infection.
Vitamin D is involved in the production of defensins and cathelicidin - antimicrobial peptides that provide a natural defence against potential microbiological pathogens. Vitamin D supplementation increases cathelicidin production. Low vitamin D levels are associated with an increased incidence of upper respiratory tract infections.
Vitamin D appears to play an important role in the regulation of innate immunity in the upper respiratory tract. Optimal vitamin D levels and appropriate dosing schedules have yet to be determined.
在二十世纪之交，紫外线被成功用于治疗皮肤结核病。上呼吸道感染与阳光照射呈负相关。在过去十年中，基础科学研究表明维生素D具有重要的抗感染作用。
回顾关于维生素D对固有免疫和呼吸道感染影响的相关文献。
维生素D参与防御素和杀菌肽的产生，这些抗菌肽可对潜在的微生物病原体提供天然防御。补充维生素D可增加杀菌肽的产生。低维生素D水平与上呼吸道感染发病率增加相关。
维生素D似乎在上呼吸道固有免疫调节中起重要作用。最佳维生素D水平和适当的给药方案尚未确定。
