Martella Vito, Pinto Pierfrancesco, Buonavoglia Canio
Dipartimento di Sanità Pubblica e Zootecnia, Università degli Studi Aldo Moro di Bari, S.p. per Casamassima km 3, 70010 Valenzano, Bari, Italy.
Vet Clin North Am Small Anim Pract. 2011 Nov;41(6):1171-81. doi: 10.1016/j.cvsm.2011.08.002.
Noroviruses are recognized as emerging enteric pathogens of humans and have been identified in recent years in a number of mammalian species. The role of noroviruses as pathogens in immune-competent animals and under natural conditions remains uncertain, although both homologous and heterologous animal models are now available to investigate the pathogenesis, the immune response, and the molecular mechanism regulating norovirus infection. Recently, evidence has been gathered that noroviruses may also circulate in domestic carnivores. The zoonotic implications of these novel viruses deserve more attention, due to the strict social interactions between humans and pets.
诺如病毒被认为是新出现的人类肠道病原体，近年来已在多种哺乳动物物种中被发现。尽管现在有同源和异源动物模型可用于研究诺如病毒感染的发病机制、免疫反应和分子机制，但诺如病毒在免疫功能正常的动物和自然条件下作为病原体的作用仍不确定。最近，已有证据表明诺如病毒也可能在家养食肉动物中传播。由于人类与宠物之间密切的社会互动，这些新型病毒的人畜共患病影响值得更多关注。
