Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Virol J. 2013 Jun 4;10:176. doi: 10.1186/1743-422X-10-176.
Noroviruses are important enteric pathogens in humans and animals. Recently, we reported a novel canine norovirus (CaNoV) in dogs with diarrhea belonging to a new genogroup (GVI). No data are available on exposure of humans to this virus.
Sera from 373 small animal veterinarians and 120 age-matched population controls were tested for IgG antibodies to CaNoV by a recombinant virus like particle based enzyme-linked immunosorbent assay.
Antibodies to CaNoV were found in 22.3% of the veterinarians and 5.8% of the control group (p < 0.001). Mean corrected OD450 values for CaNoV antibodies were significantly higher in small animal veterinarians compared to the control group.
These findings suggest that CaNoV may infect humans and small animal veterinarians are at an increased risk for exposure to this virus. Additional studies are needed to assess if this virus is able to cause disease in humans.
诺如病毒是人类和动物中重要的肠道病原体。最近，我们在腹泻犬中发现了一种新型犬诺如病毒（CaNoV），属于一个新的基因型（GVI）。目前尚无人类接触该病毒的数据。
采用基于重组病毒样颗粒的酶联免疫吸附试验检测 373 名小动物兽医和 120 名年龄匹配的对照组人群血清中的 CaNoV IgG 抗体。
兽医组中抗 CaNoV 的抗体阳性率为 22.3%，对照组为 5.8%（p<0.001）。与对照组相比，小动物兽医的 CaNoV 抗体校正 OD450 值明显更高。
这些发现表明 CaNoV 可能感染人类，而小动物兽医接触该病毒的风险增加。需要进一步研究评估该病毒是否能在人类中引起疾病。
