Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, Guilford Street, London, UK.
Epilepsy Res. 2012 Feb;98(2-3):255-9. doi: 10.1016/j.eplepsyres.2011.09.004. Epub 2011 Oct 29.
This study investigated the role of underlying pathology on memory function of children with temporal lobe epilepsy (TLE). Memory was assessed in 44 children with TLE resulting from hippocampal sclerosis (HS) or dysembryoplastic neuroepithelial tumours (DNT), and 22 control children. Delayed story and paired associate recall performance was significantly more impaired in children with HS compared to those with DNT, irrespective of the affected side. Semantic memory was impaired in both HS groups, and also in the left DNT group. These results suggest a role for type, and to a lesser extent, side of pathology in the memory profile of children with TLE.
本研究探讨了潜在病理对颞叶癫痫（TLE）儿童记忆功能的影响。对 44 名因海马硬化（HS）或发育不良性神经上皮肿瘤（DNT）而导致 TLE 的儿童和 22 名对照儿童进行了记忆评估。无论受影响的侧别如何，与 DNT 患儿相比，HS 患儿的延迟故事和配对联想回忆表现明显更差。语义记忆在两个 HS 组以及左 DNT 组均受损。这些结果表明，病理类型（在一定程度上还包括侧别）在 TLE 患儿的记忆特征中起作用。
