Lopes Ana Filipa, Monteiro José Paulo, Fonseca Maria José, Robalo Conceição, Simões Mário Rodrigues
Faculty of Psychology, University of Coimbra, Apartado 6153, 3001-802 Coimbra, Portugal ; Neuropaediatric Unit, Garcia de Orta Hospital, Almada, Portugal.
Neuropaediatric Unit, Garcia de Orta Hospital, Almada, Portugal.
Behav Neurol. 2014;2014:218637. doi: 10.1155/2014/218637. Epub 2014 Aug 3.
Specific cognitive deficits have been identified in children with epilepsy irrespective of results on intelligence tests. Memory deficits are traditionally attributed to temporal lobe epilepsy, whereas the impact of frontal lobe epilepsy on memory functions has remained controversial. The aim of this study was the examination of memory abilities in other childhood common epilepsy syndromes (frontal lobe epilepsy (FLE), childhood absence epilepsy (CAE), and benign epilepsy with centrotemporal spikes (BECTS)) and the influence of epilepsy-related variables. Memory was examined in 90 children with epilepsy (each epilepsy group consisted of 30 children), aged 6-15, and compared with 30 control children. Children with FLE showed significant deficits in verbal and visual memory. In addition, type of epilepsy, earlier age at epilepsy onset, and longer active duration of epilepsy were associated with memory problems. Seizure frequency and treatment, however, did not influence memory performance. This study indicates that children with FLE show greater risk of developing memory deficits than children with CAE or BECTS, thus highlighting the importance of assessing also memory functions in frontal lobe epilepsy.
已确定癫痫患儿存在特定的认知缺陷，无论其智力测试结果如何。传统上，记忆缺陷归因于颞叶癫痫，而额叶癫痫对记忆功能的影响一直存在争议。本研究的目的是检查其他儿童常见癫痫综合征（额叶癫痫（FLE）、儿童失神癫痫（CAE）和伴有中央颞区棘波的良性癫痫（BECTS））的记忆能力以及癫痫相关变量的影响。对90名6至15岁的癫痫儿童（每个癫痫组由30名儿童组成）进行了记忆测试，并与30名对照儿童进行了比较。FLE患儿在言语和视觉记忆方面存在显著缺陷。此外，癫痫类型、癫痫发病年龄较早以及癫痫活动持续时间较长与记忆问题有关。然而，癫痫发作频率和治疗并未影响记忆表现。这项研究表明，与CAE或BECTS患儿相比，FLE患儿出现记忆缺陷的风险更大，从而凸显了在额叶癫痫中评估记忆功能的重要性。
