Molecular Physiology Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Instituto Nacional de Cardiología Ignacio Chávez, and Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Med Princ Pract. 2012;21(2):101-14. doi: 10.1159/000332580. Epub 2011 Oct 25.
The understanding of the independent regulation of sodium and potassium by the kidney has remained elusive. Recent evidence now points to dissimilar regulatory mechanisms in ion handling, dependent on the presence of either aldosterone alone or angiotensin II with aldosterone among other factors. This review summarizes past and present information in an attempt to reconcile the current concepts of differential regulation of sodium and potassium balance through the with-no-lysine (K) kinase (WNK) system and the previous knowledge regarding ion transport mechanisms in the distal nephron.
肾脏对钠和钾的独立调节作用一直难以捉摸。最近的证据表明，离子处理的调节机制不同，这取决于醛固酮或血管紧张素 II 与醛固酮等其他因素的存在。本文综述了过去和现在的信息，试图调和目前通过无赖氨酸 (K) 激酶 (WNK) 系统对钠和钾平衡的差异调节的概念，以及以前关于远曲小管离子转运机制的知识。
