跨器官-血液屏障的定向流体运输：生理学与细胞生物学
Directional Fluid Transport across Organ-Blood Barriers: Physiology and Cell Biology.
作者信息
Caceres Paulo S, Benedicto Ignacio, Lehmann Guillermo L, Rodriguez-Boulan Enrique J
机构信息
Margaret Dyson Vision Research Institute, Department of Ophthalmology, Weill Cornell Medical College, New York, New York 10065.
出版信息
Cold Spring Harb Perspect Biol. 2017 Mar 1;9(3):a027847. doi: 10.1101/cshperspect.a027847.
Abstract
Directional fluid flow is an essential process for embryo development as well as for organ and organism homeostasis. Here, we review the diverse structure of various organ-blood barriers, the driving forces, transporters, and polarity mechanisms that regulate fluid transport across them, focusing on kidney-, eye-, and brain-blood barriers. We end by discussing how cross talk between barrier epithelial and endothelial cells, perivascular cells, and basement membrane signaling contribute to generate and maintain organ-blood barriers.
摘要
定向流体流动是胚胎发育以及器官和机体稳态的一个重要过程。在此，我们综述了各种器官 - 血屏障的不同结构、驱动流体跨屏障转运的驱动力、转运体和极性机制，重点关注肾 - 血屏障、眼 - 血屏障和脑 - 血屏障。最后，我们讨论了屏障上皮细胞与内皮细胞、血管周细胞以及基底膜信号之间的相互作用如何有助于生成和维持器官 - 血屏障。
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