Nelson R W, Himsel C A, Feldman E C, Bottoms G D
Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
Am J Vet Res. 1990 Sep;51(9):1357-62.
Glucose tolerance and insulin response were evaluated in 9 normal-weight and 6 obese cats after IV administration of 0.5 g of glucose/kg of body weight. Blood samples for glucose and insulin determinations were collected immediately prior to and 2.5, 5, 7.5, 10, 15, 30, 45, 60, 90, and 120 minutes after glucose infusion. Baseline glucose concentrations were not significantly different between normal-weight and obese cats; however, mean +/- SEM glucose tolerance was significantly impaired in obese vs normal-weight cats after glucose infusion (half time for glucose disappearance in serum--77 +/- 7 vs 51 +/- 4 minutes, P less than 0.01; glucose disappearance coefficient--0.95 +/- 0.10 vs 1.44 +/- 0.10%/min, P less than 0.01; insulinogenic index--0.20 +/- 0.02 vs 0.12 +/- 0.01, P less than 0.005, respectively). Baseline serum insulin concentrations were not significantly different between obese and normal-weight cats. Insulin peak response after glucose infusion was significantly (P less than 0.005) greater in obese than in normal-weight cats. Insulin secretion during the first 60 minutes (P less than 0.02), second 60 minutes (P less than 0.001), and total 120 minutes (P less than 0.0003) after glucose infusion was also significantly greater in obese than in normal-weight cats. Most insulin was secreted during the first hour after glucose infusion in normal-weight cats and during the second hour in obese cats. The impaired glucose tolerance and altered insulin response to glucose infusion in the obese cats was believed to be attributable to deleterious effects of obesity on insulin action and beta-cell responsiveness to stimuli (ie, glucose).
对9只体重正常的猫和6只肥胖猫静脉注射0.5克葡萄糖/千克体重后，评估其葡萄糖耐量和胰岛素反应。在葡萄糖输注前以及输注后2.5、5、7.5、10、15、30、45、60、90和120分钟采集血样，用于测定葡萄糖和胰岛素。体重正常的猫和肥胖猫的基线葡萄糖浓度无显著差异；然而，与体重正常的猫相比，肥胖猫在葡萄糖输注后的平均±标准误葡萄糖耐量显著受损（血清中葡萄糖消失的半衰期——77±7分钟对51±4分钟，P<0.01；葡萄糖消失系数——0.95±0.10%/分钟对1.44±0.10%/分钟，P<0.01；胰岛素生成指数——0.20±0.02对0.12±0.01，P<0.005）。肥胖猫和体重正常的猫的基线血清胰岛素浓度无显著差异。肥胖猫在葡萄糖输注后的胰岛素峰值反应显著（P<0.005）高于体重正常的猫。在葡萄糖输注后的前60分钟（P<0.02）、第二个60分钟（P<0.001）以及总共120分钟（P<0.0003）内，肥胖猫的胰岛素分泌也显著高于体重正常的猫。在体重正常的猫中，大多数胰岛素在葡萄糖输注后的第一小时分泌，而在肥胖猫中则在第二小时分泌。肥胖猫葡萄糖耐量受损以及对葡萄糖输注的胰岛素反应改变被认为归因于肥胖对胰岛素作用和β细胞对刺激（即葡萄糖）反应性的有害影响。
