Bushra Rabia, Aslam Nousheen
Ziauddin College of Pharmacy, Ziauddin University, Kaarchi, Sindh, Pakistan.
Oman Med J. 2010 Jul;25(3):155-1661. doi: 10.5001/omj.2010.49.
Ibuprofen was the first member of Propionic acid derivatives introduced in 1969. It is a popular domestic and over the counter analgesic and antipyretic for adults and children. Ibuprofen has been rated as the safest conventional NSAID by spontaneous adverse drug reaction reporting systems in the UK. This article summarizes the main pharmacological effects, therapeutical applications and adverse drug reactions, drug-drug interactions and food drug interactions of ibuprofen that have been reported especially during the last 10 years.
布洛芬是1969年推出的丙酸衍生物中的首个成员。它是一种深受成人和儿童欢迎的家用及非处方止痛和解热药物。在英国，通过自发药物不良反应报告系统，布洛芬被评为最安全的传统非甾体抗炎药。本文总结了布洛芬的主要药理作用、治疗应用、药物不良反应、药物相互作用以及食物与药物相互作用，尤其是过去10年期间报道的相关内容。
