Ahmed Samrah, de Jager Celeste, Wilcock Gordon
Oxford Project to Investigate Memory and Ageing (OPTIMA), Nuffield Department of Medicine, Anatomy and Genetics, University of Oxford, Oxford, UK.
Neurocase. 2012;18(4):336-51. doi: 10.1080/13554794.2011.608365. Epub 2011 Nov 2.
We report a pilot investigation into the utility of screening tools in Mild Cognitive Impairment (MCI). The Addenbrooke's Cognitive Examination-Revised (ACE-R), Montreal Cognitive Assessment (MoCA) and the novel Computer-Administered Neuropsychological Screen for Mild Cognitive Impairment (CANS-MCI) were administered to 20 elderly controls and 15 MCI cases. Non-parametric Mann-Whitney U-tests showed significant differences between groups (p < .0001) on the CANS-MCI and MoCA. The ACE-R and MoCA total scores showed high sensitivity (90%) to MCI. Area under the curve was consistently significant in discriminating controls and MCI for memory scores across all screening instruments. A useful profile of quantitative and qualitative information pertaining to cognitive functioning in MCI can be obtained with the MoCA, ACE-R, and CANS-MCI.
我们报告了一项关于筛查工具在轻度认知障碍（MCI）中的效用的初步调查。对20名老年对照者和15例MCI患者进行了修订版的Addenbrooke认知检查（ACE-R）、蒙特利尔认知评估（MoCA）以及新型的计算机辅助轻度认知障碍神经心理筛查（CANS-MCI）。非参数曼-惠特尼U检验显示，在CANS-MCI和MoCA上，两组之间存在显著差异（p < .0001）。ACE-R和MoCA总分对MCI表现出高敏感性（90%）。在所有筛查工具中，曲线下面积在区分对照者和MCI的记忆分数方面始终具有显著性。使用MoCA、ACE-R和CANS-MCI可以获得与MCI认知功能相关的有用的定量和定性信息概况。
