Na Seunghee, Kim Young Ju, Kim Si Eun, Jung Na-Yeon, Kim Seung Joo, Kim Hee Jin, Shin Joon Soo, Na Duk L, Seo Sang Won, Kim Yeshin, Lee Eek-Sung
Department of Neurology, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Dement Neurocogn Disord. 2024 Oct;23(4):224-235. doi: 10.12779/dnd.2024.23.4.224. Epub 2024 Oct 23.
We aimed to develop the diagnostic matrix of the Seoul Cognitive Status Test (SCST) and compare its performance with traditional paper-and-pencil neuropsychological tests, including the Seoul Neuropsychological Screening Battery-II (SNSB-II) and the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K).
We recruited 197 participants from the head-to-head SCST-SNSB cohort, and 204 participants from the head-to-head SCST-CERAD cohort. They underwent either SNSB-II or CERAD-K, in addition to SCST. The diagnostic matrix was developed by combining cognitive function, determined by neuropsychological tests, and activities of daily living (ADL), determined by Instrumental-ADL scales.
The diagnostic agreement between the SCST and the SNSB-II was 83.9% (weighted kappa=0.87). The agreement between the SCST and the CERAD-K was 84.3% (weighted kappa=0.88). In the SCST-SNSB cohort, all differences in SCST scores between the cognitively unimpaired (CU), mild cognitive impairment (MCI), and dementia diagnosed with the SNSB-II were significant in all cognitive domains (all <0.01), except for the executive domain between CU and MCI (=0.145). In the SCST-CERAD cohort, all differences in SCST scores between the 3 groups diagnosed with the CERAD-K were significant in all cognitive domains (all <0.01), except for the language and visuospatial domains between MCI and dementia (=0.169 and =0.778, respectively).
Our findings suggest that the tablet-based SCST may be another option to traditional paper-and-pencil neuropsychological tests, especially in situations where time and space are relatively limited, and neuropsychological testing specialists are not available.
我们旨在开发首尔认知状态测试（SCST）的诊断矩阵，并将其性能与传统的纸笔神经心理学测试进行比较，包括首尔神经心理学筛查量表-II（SNSB-II）和韩国版阿尔茨海默病注册协会（CERAD-K）。
我们从SCST-SNSB对头队列中招募了197名参与者，从SCST-CERAD对头队列中招募了204名参与者。除了SCST外，他们还接受了SNSB-II或CERAD-K测试。诊断矩阵是通过结合神经心理学测试确定的认知功能和工具性日常生活活动量表确定的日常生活活动（ADL）来开发的。
SCST与SNSB-II之间的诊断一致性为83.9%（加权kappa=0.87）。SCST与CERAD-K之间的一致性为84.3%（加权kappa=0.88）。在SCST-SNSB队列中，除了CU和MCI之间的执行领域（=0.145）外，认知未受损（CU）、轻度认知障碍（MCI）和经SNSB-II诊断为痴呆的患者在所有认知领域的SCST分数差异均具有统计学意义（均<0.01）。在SCST-CERAD队列中，经CERAD-K诊断的三组患者在所有认知领域的SCST分数差异均具有统计学意义（均<0.01），除了MCI和痴呆之间的语言和视觉空间领域（分别为=0.169和=0.778）。
我们的研究结果表明，基于平板电脑的SCST可能是传统纸笔神经心理学测试的另一种选择，特别是在时间和空间相对有限且没有神经心理学测试专家的情况下。
