Department of Clinical Research, Faculty of Allied Health Sciences, Jamia Hamdard (Hamdard University), New Delhi-110062, India.
Fundam Clin Pharmacol. 2013 Apr;27(2):169-72. doi: 10.1111/j.1472-8206.2011.01002.x. Epub 2011 Nov 2.
Contemporary research indicates promising anticonvulsant effect of curcumin. However, its poor oral bioavailability is a major hindrance toward its pharmacological action. Thus, this study was carried out to evaluate the acute effect of liposome-entrapped curcumin on increasing current electroshock seizures (ICES) test, pentylenetetrazole (PTZ)-induced seizures, and status epilepticus in mice. Liposome-entrapped curcumin in doses 25 and 50 mg/kg demonstrated significant increase in seizure threshold current and latency to myoclonic and generalized seizures in ICES test and PTZ-induced seizures, respectively. Similarly, liposomal-entrapped curcumin also increased the latency to the onset and decreased the duration of seizures during status epilepticus in mice. To conclude, liposomal-entrapped curcumin possesses anticonvulsant activity against status epilepticus in mice.
当代研究表明姜黄素具有有前景的抗惊厥作用。然而，其较差的口服生物利用度是其药理作用的主要障碍。因此，本研究旨在评估脂质体包封姜黄素对增加电流惊厥（ICES）试验、戊四氮（PTZ）诱导的惊厥和小鼠癫痫持续状态的急性作用。脂质体包封姜黄素在 25 和 50 mg/kg 剂量下，在 ICES 试验和 PTZ 诱导的惊厥中分别显著增加惊厥阈电流和肌阵挛和全身性惊厥的潜伏期。同样，脂质体包封姜黄素还增加了癫痫持续状态小鼠发作开始的潜伏期，并缩短了发作持续时间。总之，脂质体包封姜黄素具有抗癫痫持续状态的活性。
