University Francois Rabelais, Tours, France.
J Eur Acad Dermatol Venereol. 2012 Oct;26(10):1285-90. doi: 10.1111/j.1468-3083.2011.04285.x. Epub 2011 Nov 2.
Two types of neonatal haemangiomatosis (NH) are distinguished: diffuse which is associated with a high rate of mortality linked to mucosal/visceral involvement, and benign.
First, this study aimed to examine the frequency of mucosal and visceral (especially hepatic) involvement in NH, according to skin extension, and second, it aimed to examine clinical, pathological (with glucose transporter 1 (GLUT-1) immunostaining), and imaging features of NH, including follow-up data.
This was a descriptive retrospective study carried out in the University Hospital Center of Tours, France.
The study included 19 patients with cutaneous NH (number of skin haemangiomas ranging from 5 to >100). Mucosal involvement was observed in 32% of all cases (100% and 19% in diffuse and other cutaneous cases respectively) and hepatic involvement in 42% (67% and 38% respectively). The number of hepatic haemangiomas ranged from 1 to >10. Half of the hepatic haemangiomas cases exhibited increased hepatic arterial blood flow.
Mucosal and hepatic involvement was frequent in cases with a high number of cutaneous haemangiomas (>100), but only frequency of mucosal involvement was statistically significant (P = 0.021).
新生儿血管瘤（NH）分为两种类型：弥漫性，其死亡率高，与黏膜/内脏受累有关；良性。
本研究首先旨在根据皮肤受累程度，检查 NH 黏膜和内脏（特别是肝脏）受累的频率，其次，检查 NH 的临床、病理（葡萄糖转运蛋白 1 [GLUT-1] 免疫染色）和影像学特征，包括随访数据。
这是一项在法国图尔大学医院中心进行的描述性回顾性研究。
研究纳入了 19 例皮肤 NH 患者（皮肤血管瘤数量从 5 个到>100 个）。所有病例中黏膜受累的比例为 32%（弥漫性和其他皮肤型分别为 100%和 19%），肝脏受累的比例为 42%（分别为 67%和 38%）。肝脏血管瘤的数量从 1 个到>10 个不等。半数肝脏血管瘤病例显示肝动脉血流增加。
皮肤血管瘤数量多（>100 个）的病例中黏膜和肝脏受累较常见，但只有黏膜受累的频率具有统计学意义（P = 0.021）。
