Till Christine, Deotto Angela, Tipu Vicentiu, Sled John G, Bethune Allison, Narayanan Sridar, Arnold Doug L, Banwell Brenda L
Department of Psychology, York University, 4700 Keele Street, Toronto, Canada.
Neuroreport. 2011 Dec 21;22(18):1005-9. doi: 10.1097/WNR.0b013e32834dc301.
Multiple sclerosis is associated with reduced white matter integrity and deficits in key cognitive processes important for arithmetic. This study examined the relationship between white matter microstructure and academic ability in 31 youths with multiple sclerosis (aged 11-19 years) and 34 demographically matched controls. Using diffusion tensor imaging, fractional anisotropy was calculated in corpus callosum and in lateralized hemispheric lobes. Difficulties with written arithmetic ability were observed in 26% of patients. Arithmetic ability correlated with fractional anisotropy values across all segments of the corpus callosum and in right frontal and parietal regions, controlling for age (r values >0.5, P<0.005). Findings highlight the functional impact of compromised white matter microstructure across diffuse regions of the brain on mathematical ability.
多发性硬化症与白质完整性降低以及对算术至关重要的关键认知过程缺陷有关。本研究调查了31名患有多发性硬化症的青少年（年龄在11 - 19岁之间）和34名人口统计学匹配的对照组的白质微观结构与学业能力之间的关系。使用扩散张量成像，计算胼胝体和半球侧化叶的分数各向异性。26%的患者存在书面算术能力困难。在控制年龄的情况下，算术能力与胼胝体所有节段以及右侧额叶和顶叶区域的分数各向异性值相关（r值>0.5，P<0.005）。研究结果突出了大脑弥散区域白质微观结构受损对数学能力的功能影响。
