Department of Pediatrics, School of Medicine, Mustafa Kemal University, Hatay, Turkey.
Hum Exp Toxicol. 2012 Jun;31(6):574-8. doi: 10.1177/0960327111426588. Epub 2011 Nov 1.
In this study, the effects of erdosteine (ED) on the platelet function and coagulation were investigated in adult rats.
Twenty-eight male Wistar albino rats were divided into four groups. The control rats in group I (n = 7) were given only 0.5 cc of normal saline daily through oral gavage. Group II (n = 7) rats were administered 3 mg/kg ED through oral gavage for 3 days; while group III (n = 7) rats were given 10 mg/kg ED through oral gavage for 3 days; and group IV (n = 7) rats were administered 30 mg/kg ED through oral gavage for 3 days. Prothrombin time (PT), activated prothromboplastin time (aPTT), international normalized ratio (INR), coagulation factors and complete blood counts were measured from the blood drawn.
There were a lot of differences between ED groups and control group, and among ED groups. The found differences were level of PT, aPTT, INR, coagulation factors, and number of platelets.
We consider that ED which is used as a mucolytic agent in child clinics may affect hemostasis and coagulation in a dose-dependent manner. ED should be used carefully by the patients with coagulation disorders, since there is no information available in the package insert and literature screening regarding the effect of ED.
本研究旨在观察厄多司坦（ED）对成年大鼠血小板功能和凝血的影响。
28 只雄性 Wistar 白化大鼠随机分为 4 组。I 组（n = 7）仅给予 0.5 cc 生理盐水每日灌胃；II 组（n = 7）给予 3 mg/kg ED 每日灌胃 3 天；III 组（n = 7）给予 10 mg/kg ED 每日灌胃 3 天；IV 组（n = 7）给予 30 mg/kg ED 每日灌胃 3 天。从采血中测量凝血酶原时间（PT）、活化部分凝血活酶时间（aPTT）、国际标准化比值（INR）、凝血因子和全血细胞计数。
ED 组与对照组、ED 组之间存在明显差异。差异主要表现为 PT、aPTT、INR、凝血因子和血小板数量的改变。
我们认为，ED 作为儿科临床的黏液溶解剂，可能会以剂量依赖的方式影响止血和凝血。由于 ED 的包装说明书和文献筛查中均未提及对其对凝血功能的影响，因此，对于有凝血障碍的患者，应谨慎使用 ED。
