Departments of Pathology and Genome Sciences, University of Washington, Seattle, Washington, 98195-7470, USA.
FASEB J. 2011 Nov;25(11):3756-62. doi: 10.1096/fj.11-1102.ufm.
In this contribution to the series of reflective essays celebrating the 25th anniversary of The FASEB Journal, our task is to assess the growth of research on the biology of aging during this period and to suggest where we might be heading during the next 25 yr. A review of the literature suggests a healthy acceleration of progress during the past decade, perhaps largely due to progress on the genetics of longevity of model organisms. Progress on the genetics of health span in these model organisms has lagged, however. Research on the genetic basis of the remarkable interspecific variations in life span has only recently begun to be seriously addressed. The spectacular advances in genomics should greatly accelerate progress. Research on environmental effects on life span and health span needs to be accelerated. Stochastic variations in gene expression in aging have only recently been addressed. These can lead to random departures from homeostasis during aging.-Martin, G. M. The biology of aging: 1985-2010 and beyond.
在这篇为庆祝《FASEB 杂志》创刊 25 周年而撰写的反思性文章系列中，我们的任务是评估在此期间衰老生物学研究的发展，并对未来 25 年的发展方向提出建议。对文献的回顾表明，过去十年的进展相当健康，这或许在很大程度上是由于模式生物的长寿遗传学方面的进展。然而，这些模式生物的健康跨度遗传学研究却滞后了。对寿命的显著种间变化的遗传基础的研究直到最近才开始得到认真解决。基因组学的惊人进展应该会大大加速这一进程。关于环境对寿命和健康跨度影响的研究需要加速。衰老过程中基因表达的随机变化最近才得到解决。这些变化会导致衰老过程中体内平衡的随机偏离。——马丁，GM 衰老的生物学：1985-2010 及以后。
