Zhao Jingmin, Imai Ryota, Ukon Naoyuki, Shimoyama Saki, Tan Chengbo, Maejima Yuko, Omiya Yuji, Takahashi Kazuhiro, Nan Guangxian, Zhao Songji, Ito Hiroshi, Shimomura Kenju
Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
Department of Radiology and Nuclear Medicine, Fukushima Medical University, Fukushima, Japan.
Front Nutr. 2021 May 12;8:657663. doi: 10.3389/fnut.2021.657663. eCollection 2021.
A recent clinical study revealed that Ninjin'yoeito (NYT) may potentially improve cognitive outcome. However, the mechanism by which NYT exerts its effect on elderly patients remains unclear. The aim of this study is to evaluate the effect of Ninjin'yoeito on regional brain glucose metabolism by F-FDG autoradiography with insulin loading in aged wild-type mice. After 12 weeks of feeding NYT, mice were assigned to the control and insulin-loaded groups and received an intraperitoneal injection of human insulin (2 U/kg body weight) 30 min prior to F-FDG injection. Ninety minutes after the injection, brain autoradiography was performed. After insulin loading, the F-FDG accumulation showed negative changes in the cortex, striatum, thalamus, and hippocampus in the control group, whereas positive changes were observed in the NYT-treated group. Ninjin'yoeito may potentially reduce insulin resistance in the brain regions in aged mice, thereby preventing age-related brain diseases.
最近的一项临床研究表明，人参养荣汤（NYT）可能会改善认知结果。然而，NYT对老年患者发挥作用的机制尚不清楚。本研究的目的是通过在老年野生型小鼠中进行胰岛素负荷的F-FDG放射自显影术来评估人参养荣汤对局部脑葡萄糖代谢的影响。喂食NYT 12周后，将小鼠分为对照组和胰岛素负荷组，并在注射F-FDG前30分钟腹腔注射人胰岛素（2 U/kg体重）。注射后90分钟，进行脑放射自显影术。胰岛素负荷后，对照组的皮质、纹状体、丘脑和海马体中F-FDG积聚呈现负向变化，而NYT治疗组则观察到正向变化。人参养荣汤可能会降低老年小鼠脑区的胰岛素抵抗，从而预防与年龄相关的脑部疾病。
