Brain area specific regulation of synaptic AMPA receptors by phosphorylation.

Regulation of synaptic AMPA receptors (AMPARs) is one of the key elements that allow the nervous system to adapt to changes in the sensory environment as well as for memory formation. One way to regulate AMPAR function is by reversible changes in the phosphorylation of its subunits. We recently reported that phosphorylation of the AMPAR subunit GluA1 (or GluR1) on serine-845 (S845) is a pre-requisite step for sensory experience-dependent homeostatic synaptic plasticity in the visual cortex. In particular, increasing GluA1-S845 phosphorylation upregulated cell surface and synaptic AMPAR levels. Here we report that this is rather specific to the visual cortex, in that increasing GluA1-S845 phosphorylation in hippocampal slices only increase cell surface expression, but not synaptic AMPAR function. Our results suggest that depending on the brain region divergent mechanisms may exist to regulate synaptic AMPAR function with phosphorylation.