TTF-1 阳性小细胞癌：不要认为它们总是原发性肺的！
TTF-1 positive small cell cancers: Don't think they're always primary pulmonary!
机构信息
Laurine Verset, Myriam Remmelink, Pieter Demetter, Departments of Pathology, Erasme University Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium.
出版信息
World J Gastrointest Oncol. 2011 Oct 15;3(10):144-7. doi: 10.4251/wjgo.v3.i10.144.
Abstract
Thyroid transcription factor 1 (TTF-1) plays a key role in morphogenesis of the lungs and is expressed in up to 90% of pulmonary small cell carcinomas. This explains why this marker is frequently used in the search for the primary origin of metastatic endocrine tumours. Here we report on a TTF-1 expressing mixed endocrine-exocrine carcinoma of the common bile duct in a patient with pulmonary nodules that did not appear to be neoplastic. TTF-1 positivity in pulmonary and extrapulmonary neuroendocrine tumours is reviewed, and we conclude that TTF-1 expression in neuroendocrine tumours of the small-cell type are not uncommon at extrapulmonary locations. Therefore, immunohistochemistry for TTF-1 in such tumours should be interpreted with caution.
摘要
甲状腺转录因子 1（TTF-1）在肺的形态发生中起关键作用，并且在多达 90%的肺小细胞癌中表达。这就解释了为什么这个标志物经常用于寻找转移性内分泌肿瘤的原发部位。在这里，我们报告了一例 TTF-1 表达的混合性内分泌-外分泌胆管癌，患者肺部结节无明显肿瘤表现。我们回顾了肺内和肺外神经内分泌肿瘤中 TTF-1 的阳性表达情况，并得出结论，在肺外部位小细胞型神经内分泌肿瘤中 TTF-1 的表达并不罕见。因此，对于此类肿瘤的 TTF-1 免疫组化检测应谨慎解读。
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