Muñoz Sanchez Pedro Jose, Capote Femenías José Luis, Díaz Tejeda Alejandro, Tunér Jan
Leonardo Fernández Sánchez Dental Clinic, Cienfuegos, Cuba.
Photomed Laser Surg. 2012 Jan;30(1):37-40. doi: 10.1089/pho.2011.3076. Epub 2011 Nov 2.
The purpose of this work was to study the effect of low-level laser therapy (LLLT) on the healing and relapse intervals in patients with recurrent labial herpes simplex infections.
Several pharmaceuticals are available to reduce symptoms and improbé healing of labial herpes, but only LLLT has been reported to significantly influence the length of the recurrence period.
In an initial study, 232 patients with herpes simplex type 1 virus symptoms were consecutively selected for either LLLT or conventional therapy, including acyclovir cream or tablets. One of the dentists was responsible for the diagnosis, a second dentist for the treatment, and and a third for the evaluation, to allow for a semi-blinded procedure. Patients in the laser group received 670-nm laser irradiation, 40 mW, 1.6 J, 2.04 J/cm(2), 51 mW/cm(2) per blister in the prodromal stage and 4.8 J in the crust and secondarily infected stages, plus 1.2 J at the C2-C3 vertebrae. Patients were monitored daily during the first week to control healing, and monthly for 1 year to check on recurrence. In a consecutive study, 322 patients receiving LLLT were followed during 5 years to observe the period of ocurrences.
An obvious effect of LLLT was found for both initial healing and for the length of the recurrence periods.
LLLTof herpes simples virus 1 (HSV-1) appears to be an effective treatment modality without any observed side effects.
本研究旨在探讨低强度激光疗法（LLLT）对复发性唇疱疹单纯感染患者愈合及复发间隔的影响。
有多种药物可用于减轻唇疱疹症状并促进愈合，但据报道只有LLLT能显著影响复发期的时长。
在一项初步研究中，连续选取232例有1型单纯疱疹病毒症状的患者，分为LLLT组或接受包括阿昔洛韦乳膏或片剂在内的传统治疗组。一名牙医负责诊断，另一名牙医负责治疗，第三名牙医负责评估，以实现半盲法操作。激光组患者在前驱期每个水疱接受波长670nm、功率40mW、能量1.6J、能量密度2.04J/cm²、功率密度51mW/cm²的激光照射，结痂及继发感染期接受4.8J照射，同时在C2 - C3椎体处接受1.2J照射。在第一周每天对患者进行监测以控制愈合情况，在1年内每月进行检查以查看复发情况。在一项连续研究中，对322例接受LLLT的患者进行了5年随访以观察发病周期。
发现LLLT对初始愈合及复发期时长均有明显效果。
1型单纯疱疹病毒（HSV - 1）的LLLT似乎是一种有效的治疗方式，且未观察到任何副作用。
