Honarmand Marieh, Farhadmollashahi Leila, Vosoughirahbar Ehsan
Associated Professor, Oral and Dental Disease Research Center, Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
Associated professor, Oral and Dental Disease Research Center, Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
J Clin Exp Dent. 2017 Jun 1;9(6):e729-e732. doi: 10.4317/jced.53679. eCollection 2017 Jun.
Recently alternative therapies such as the use of diode laser therapy have been introduced for recurrent herpes labial infection. The aim of this study was to evaluate the effectiveness of diode laser for treatment of recurrent herpes labialis.
This was single-blind randomized clinical trial to evaluate the efficacy of diode laser for the treatment of recurrent herpes labial. In total, 60 patients whit recurrent herpes simplex labialis were selected and randomly divided in to three groups. 20 patients received treatment whit diode laser (at a wavelength of 870 nm, energy density 4.5 j/cm2), 20 patients were treated with acyclovir cream 5%, 20 patients received treatment with laser-off (placebo). The end point was lesions crusting. Data analyzed by Tukey HSD Test and One-way ANOVA (at a significance level of 0.05) in SPSS-20 software.
The mean length of recovery time (day) in the laser, off laser, and acyclovir groups was 2.20±0.41, 4.30±1.03, and 3.4±1.142, respectively. There is a significant difference between three groups in this regard (<0.0001). The mean duration of pain (day) was 1.35±0.74, 2.65±1.27, and 2.30±0.92 for laser, off laser, and acyclovir groups, respectively (<0.0001).
Treatment with diode laser reduced the length of recovery time and pain severity faster than treatment with acyclovir cream. Recurrent herpes labial, Acyclovir, Low level laser therapy.
最近，诸如使用二极管激光疗法等替代疗法已被引入复发性唇疱疹感染的治疗。本研究的目的是评估二极管激光治疗复发性唇疱疹的有效性。
这是一项单盲随机临床试验，旨在评估二极管激光治疗复发性唇疱疹的疗效。总共选择了60例复发性单纯性唇疱疹患者，并随机分为三组。20例患者接受二极管激光治疗（波长870nm，能量密度4.5j/cm²），20例患者用5%阿昔洛韦乳膏治疗，20例患者接受激光关闭治疗（安慰剂）。终点是皮损结痂。数据在SPSS - 20软件中通过Tukey HSD检验和单因素方差分析（显著性水平为0.05）进行分析。
激光组、激光关闭组和阿昔洛韦组的平均恢复时间（天）分别为2.20±0.41、4.30±1.03和3.4±1.142。在这方面三组之间存在显著差异（<0.0001）。激光组、激光关闭组和阿昔洛韦组的平均疼痛持续时间（天）分别为1.35±0.74、2.65±1.27和2.30±0.92（<0.0001）。
与阿昔洛韦乳膏治疗相比，二极管激光治疗能更快缩短恢复时间并减轻疼痛严重程度。复发性唇疱疹、阿昔洛韦、低强度激光疗法。
