Marotti Juliana, Sperandio Felipe Fornias, Fregnani Eduardo Rodrigues, Aranha Ana Cecilia Corrêa, de Freitas Patrícia Moreira, Eduardo Carlos de Paula
Department of Prosthodontics/Special Laboratory of Lasers in Dentistry (LELO), School of Dentistry, University of São Paulo, São Paulo, Brazil.
Photomed Laser Surg. 2010 Jun;28(3):439-44. doi: 10.1089/pho.2009.2522.
The aim of this study was to report the treatment of recurrent herpes labialis (RHL) using a high-intensity laser or methylene blue (MB)-mediated photodynamic therapy (PDT) in combination with low-level laser therapy (LLLT).
Four clinical cases of patients diagnosed with RHL are described in this report. Two patients were subjected to high-intensity laser therapy (HILT) followed by LLLT, and two patients received MB-mediated PDT, again followed by LLLT. LLLT was conducted at 24, 48, 72 h, and 7 d after HILT or PDT. Patients were followed up after 6 mo.
Throughout the follow-up period, all patients reported pain relief and did not show any signs or symptoms of RHL. A favorable healing process was observed in all cases. None of the patients reported pain as a consequence of the treatment.
These results suggest that HILT and MB-mediated PDT, in combination with LLLT, may constitute a benefit when treating vesicles in RHL.
本研究的目的是报告使用高强度激光或亚甲蓝（MB）介导的光动力疗法（PDT）联合低强度激光疗法（LLLT）治疗复发性唇疱疹（RHL）的情况。
本报告描述了4例诊断为RHL的临床病例。2例患者先接受高强度激光治疗（HILT），然后进行LLLT，另外2例患者接受MB介导的PDT，同样随后进行LLLT。LLLT在HILT或PDT后的24、48、72小时和7天进行。患者在6个月后进行随访。
在整个随访期间，所有患者均报告疼痛缓解，且未出现RHL的任何体征或症状。所有病例均观察到良好的愈合过程。没有患者报告治疗引起的疼痛。
这些结果表明，HILT和MB介导的PDT联合LLLT在治疗RHL中的水疱时可能有益。
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